Skip to content


Visit our Crisis Assistance Link for resources. For immediate help, get to the ER.

*No Dr Outside Contact Please*
Includes Expert Content
Dr. G-Lamictal question
midge6869 posted:
Hi Dr. G, my pdoc increased my dosage of Lamictal on December 10th from 350mg to 400mg, and said if that didnt do it he might add some topomax or seroquel. I was just wondering if 2 weeks was enough time to see if the increased dosage was helping. Thank you.
Joseph F Goldberg, MD responded:
Dear midge6869,

In the studies done by the manufacturer of Lamictal, there were no differences in antidepressant efficacy when comparing 200 vs. 400 mg/day so I would imagine that an increase from 350 to 400 mg would be unlikely to convert a nonresponse to a response (it might fine-tune an existing response). Seroquel is the best- and most-extensively studied remedy for bipolar depression, with a target dose of 300 mg/day, and is compatible with lamotrigine (and may have synergistic effects). Topamax has no known antidepressant or antimanic properties, but has been shown to cause depression in people with mood disorders.

Dr. G.
midge6869 responded:
Thanks again Dr. G.

Featuring Experts

Joseph F. Goldberg, MD, is a Clinical Professor of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY. He also maintains a private prac...More

Helpful Tips

NSAIDS and lithiumExpert
Nonsteroidal anti-inflammatory drugs (eg, Motrin/ibuprofen, Advil, Naprosyn) raise lithium levels by about 20%. We often therefore say ... More
Was this Helpful?
73 of 97 found this helpful

Related Drug Reviews

  • Drug Name User Reviews

Report Problems With Your Medications to the FDA

FDAYou are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.