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episodes since late teens. He has every typical symptom of the mania (and depression) and has been in a
current manic episode for over 3 months. With this last episode all the symptoms became much worse, he has
developed extreme hostility/rage, and has been horribly verbally and emotionally abusive to my daughter and
grandchildren. He was never medically treated until recently when this last episode of mania got so destructive
he finally agreed to treatment. (His parents don't think mental illness is real, that medications shouldn't be
taken for mental illness, that their son couldn't possibly be afflicted with manic depression, and think any
problems he has can be solved through Christian marriage counseling and prayer. They have heavily
influenced his decisions/actions up to this point.) He lives in a small rural community with mental health care
limited to a county mental health facility. He is seeing a therapist once a week and a nurse practitioner
(NP) once every 3 weeks. Possibly because of his underlying fears/doubts of taking mental health medications
originating from his parents and now verbalized to the nurse practitioner, but it appears to me that the NP is not
prescribing the dosages needed to get out of this current manic episode and to stabilize his mood.
Current medication history: The NP originally prescribed 5mg Abilify 4.5 weeks ago. My daughter called after a
week and was told he could increase it to 10mg (and no more). The NP would not prescribe anything else until
the 2nd visit at 3 weeks. At the 2nd visit she prescribed Lamictal (25mg 1st week, 50mg 2nd week, 75mg 3rd
week, 100mg 4th week and then "we'll see from there").
Current situation: After a month on 10mg Abilify, I'd say my son-in-law is less manic but still manic
(still lots of talking, not sleeping much, grandiose thinking, making poor decisions). He has improved somewhat in that someone can 'get a work in edge-wise', he hasn't had a fit of uncontrollable rage for 2 weeks, and has stopped having delusions. But I'm questioning whether the improvement is the medication helping or if it isn't that he had already 'peaked' and has naturally started to come out of the most extreme mania on his own, which he started doing about a week prior to even starting any medications.
Question for Dr. G: I've read extensively about his medications online and based on that reading have some
concerns:
o First, for Abilify, everything I read says the average dose for bipolar is 15mg and up to 30mg. Does it sound correct the NP has him only on 10mg?
o What I've read says that it is important to stabilize the mania prior to and with something other than Lamictal; that Lamictal is for preventing future episodes of mania but is ineffective to treat current episodes. He is obviously still manic, so shouldn't she have stabilized the current episode first? She seems to be counting on the Lamictal to stabilize the current episode - said it takes longer for Lamictal to do that than Abilify (due to the ramp up period for Lamictal) so that was why she started him on Abilify rather than Lamictal.
o The nurse practioner seems to be building him up to only 100mg of Lamictal and then "see". Everything I've read says the average dose for Lamictal is 200mg if not on any other bipolar meds. She has said she intends to take him off of the Abilify after he works up to the 100mg of Lamictal. That doesn't sound right to me. He's still manic. 2nd, 100mg of Lamictal sounds too low. 3rd, several things I've read said for Bipolar 1, if taking only Lamictal, the patient can still eventually break through and have a manic episode. Should he take something with the Lamictal long term?
Thanks for any advice. Possibly I'm worrying for no reason, but really need to know if they should pursue these
questions with the nurse practitioner and/or get a 2nd opinion.
Thanks.
You are correct in your statements. Lamictal is a preventative drug, mainly against recurrent depressions more so than manias, in bipolar disorder. It has no known value in acute mania (that is to say, it was studied extensively for that purpose and found to be no better than a placebo).
Abilify has somehow become the flavor of the month for treating anything and everything in the world of bipolar disorder, even though it has no antidepressant properties in bipolar disorder and has non-trivial side effects. While it is FDA-approved to treat hospitalized mania in bipolar I disorder at the 15-30 mg doses, many practitioners use it mainly as an add-on (not a solo treatment) to an antimanic drug -- most often Depakote and lithium. Depakote and lithium remains the gold standard, mainstay treatments for mania or preventions of relapses in bipolar I disorder. It may be worth asking the NP if there is a reason that she is avoiding the gold standard drugs and also why she is thinking that Lamictal has any value in acute mania given the negative published randomized trials.
Dr. G.
I am still encouraging my daughter to read what you've sent me & talk to the NP so that hasn't happened yet. Son-in-law isn't really capable of those kinds of conversations without her help (still manic and phobic about mental illness meds in general), and I think she's afraid to 'rock the boat' right now since he's finally taking any meds, not raging and in a more manageable form of mania right now.
As it stands right now, he's still on the 10mg of Abilify & now worked up to 75mg Lamictal. He seems to feel that the Lamictal is already helping. He says typically he'd start feeling depressed by now and isn't. And he says his usual feelings of negativity and aggitation (which happens apparently all the time...manic, stable, depressed) have lessened. He says he feels more clear in his head. So I think he's going to want to stay on the Lamictal and that's good for the depression. But as discussed previously, I don't think the 10mg of Abilify helped the mania at all, and once off of it (which if no one addresses any of this with the NP that's the course it's going) there is nothing helping him with the current mania and Lamictal isn't intended to prevent of future episodes of mania.
I like the idea of asking the NP about adding Depakote or lithium to address the mania. Are both of those meds compatible with Lamictal? If so, typically in what dose? (Since for the first 2 meds the NP low balled the recommended dosages, that info would be helpful going into the conversation with her.)
Thanks so much for your help.
Lamictal does have some value in preventing (but not acutely treating) mania -- it is better than a placebo for that -- but it has a much more powerful effect in preventing depressions than manias.
Lithium or Depakote are each compatible with Lamictal but if one is going to add Depakote to Lamictal, the Lamictal dose must be halved because Depakote doubles the level of Lamictal -- so, if someone is already, say, taking 100 mg of Lamictal and Depakote is added, the Lamictal would be cut down to 50 mg/day. There is no dosing adjustment when adding lithium to Lamictal.
Dr. G.
Thanks for the information. How will we know what the right amount of Lamictal is for him? (Assuming he isn't taking Depakote too), the NP had said they'd get him to 100mg and "then see". But everything I've read says the usual dose for bipolar is 200mg. Are some people OK with only 100mg? Or should we be asking/assuming he needs to work up to 200mg?
Lamictal is a "preventative" drug rather than a drug used to treat here-and-now symptoms. With the usual target dose being 200 mg/day, then 100 mg/day would be the customary target dose when combined with Depakote to optimize against a relapse.
Dr. G.
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