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    Dr. G - Seroquel and hypoglycemia
    midge6869 posted:
    Dr. G,
    Currently I take Lisinopril, Simvastatin, Naproxen, Omeprazole, Lamictal, Lexapro, and Glipizide ER. Friday night I started taking 100mg of Seroquel for bipolar depression. My morning numbers for blood sugar have always been 130 or higher, even with the Glipizide (my A1C is under 6.0). Since I started the Seroquel, my morning numbers have been in the 80's and I frequently feel hypoglycemic throughout the day. I was wondering if you have heard of Seroquel causing hypoglycemia? Also, do you think I should contact my gp and see about getting the glipizide dosage decreased?
    Thanks again for your help.
    Joseph F Goldberg, MD responded:
    Dear Midge,

    I know of no evidence that Seroquel can cause hypoglycemia. If it had any effect on raising blood sugar, it's usually no more than a few mg/dl and not something one would expect to see within only a few days of starting it. But if your morning fingersticks are running low, that could be unrelated to Seroquel and may be worth discussing with your PCP if it persists...knowing the more likely risk with Seroquel is that it may over time slightly raise blood sugar.

    Dr. G.
    midge6869 replied to Joseph F Goldberg, MD's response:
    Thanks so much !

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