Skip to content
My WebMD Sign In, Sign Up

Announcements

Visit our Crisis Assistance Link for resources. For immediate help, get to the ER.

*No Dr Outside Contact Please*
Includes Expert Content
Bipolar II, SSRIs and Mania
avatar
An_250960 posted:
Can anyone point me towards studies that show how likely it is that SSRIs (unaccompanied by mood stabilizers) will induce mania in a patient with bipolar II? Specifically, in a patient who has had hypomanic episodes but who has never had a manic episode, to what extent does going on an SSRI increase the likelihood of mania?
Reply
 
avatar
Joseph F Goldberg, MD responded:
Dear An,
For studies on antidepressant monotherapy in bipolar II depression, see: Amsterdam & Shults, Efficacy and safety of fluoxetine versus lithium monotherapy in bipolar II depressiuon. American Journal of Psychiatry July 2010 (http://www.ncbi.nlm.nih.gov/pubmed/20360317 ) and also
Parker et al., SSRIs as mood stabilizers for bipolar II depression: a proof of concept study. Journal of Affective Disorders June 2006 (http://www.ncbi.nlm.nih.gov/pubmed/?term=Parker citalopram bipolar depression )

There is also a book for professionals called Bipolar II Disorder by Dr. Gordon Parker (http://www.amazon.com/Bipolar-II-Disorder-Modelling-Measuring/dp/1107600898 ) which covers this topic in great depth.

Dr. G.
 
avatar
An_250960 replied to Joseph F Goldberg, MD's response:
Dr. G,

Thank you so much. I can't even tell you how helpful this is.


Featuring Experts

Joseph F. Goldberg, MD, is a Clinical Professor of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY. He also maintains a private prac...More

Helpful Tips

NSAIDS and lithiumExpert
Nonsteroidal anti-inflammatory drugs (eg, Motrin/ibuprofen, Advil, Naprosyn) raise lithium levels by about 20%. We often therefore say ... More
Was this Helpful?
68 of 91 found this helpful

Related News

There was an error with this newsfeed

Related Drug Reviews

  • Drug Name User Reviews

Report Problems With Your Medications to the FDA

FDAYou are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.