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Bipolar II, SSRIs and Mania
An_250960 posted:
Can anyone point me towards studies that show how likely it is that SSRIs (unaccompanied by mood stabilizers) will induce mania in a patient with bipolar II? Specifically, in a patient who has had hypomanic episodes but who has never had a manic episode, to what extent does going on an SSRI increase the likelihood of mania?
Joseph F Goldberg, MD responded:
Dear An,
For studies on antidepressant monotherapy in bipolar II depression, see: Amsterdam & Shults, Efficacy and safety of fluoxetine versus lithium monotherapy in bipolar II depressiuon. American Journal of Psychiatry July 2010 ( ) and also
Parker et al., SSRIs as mood stabilizers for bipolar II depression: a proof of concept study. Journal of Affective Disorders June 2006 ( citalopram bipolar depression )

There is also a book for professionals called Bipolar II Disorder by Dr. Gordon Parker ( ) which covers this topic in great depth.

Dr. G.
An_250960 replied to Joseph F Goldberg, MD's response:
Dr. G,

Thank you so much. I can't even tell you how helpful this is.

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