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    Bipolar II, SSRIs and Mania
    avatar
    An_250960 posted:
    Can anyone point me towards studies that show how likely it is that SSRIs (unaccompanied by mood stabilizers) will induce mania in a patient with bipolar II? Specifically, in a patient who has had hypomanic episodes but who has never had a manic episode, to what extent does going on an SSRI increase the likelihood of mania?
    Reply
     
    avatar
    Joseph F Goldberg, MD responded:
    Dear An,
    For studies on antidepressant monotherapy in bipolar II depression, see: Amsterdam & Shults, Efficacy and safety of fluoxetine versus lithium monotherapy in bipolar II depressiuon. American Journal of Psychiatry July 2010 (http://www.ncbi.nlm.nih.gov/pubmed/20360317 ) and also
    Parker et al., SSRIs as mood stabilizers for bipolar II depression: a proof of concept study. Journal of Affective Disorders June 2006 (http://www.ncbi.nlm.nih.gov/pubmed/?term=Parker citalopram bipolar depression )

    There is also a book for professionals called Bipolar II Disorder by Dr. Gordon Parker (http://www.amazon.com/Bipolar-II-Disorder-Modelling-Measuring/dp/1107600898 ) which covers this topic in great depth.

    Dr. G.
     
    avatar
    An_250960 replied to Joseph F Goldberg, MD's response:
    Dr. G,

    Thank you so much. I can't even tell you how helpful this is.


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