Skip to content

    Announcements

    Exciting News for WebMD Members!

    We've been busy behind the scenes building new message boards for you. You'll have new and easier ways to find messages, connect with others, and share your stories.

    And, this will all be available on your smartphone or other mobile device!

    What Do You Need to Do?

    The message board you're used to will be closing in the coming weeks. While many of your boards will be making the move to our new home, your posts will not. Want to keep a discussion going? Save posts you want to continue (this includes your member profile story), so that you can re-post them in the new message boards.

    Keep an eye here and on your email inbox, we'll be back in touch soon to give you all the information you need!


    Yours in health,
    WebMD Message Boards Management

    Visit our Crisis Assistance Link for resources. For immediate help, get to the ER.

    *No Dr Outside Contact Please*
    Includes Expert Content
    Dr. G. - Increase in meds.
    avatar
    Carl_1970 posted:
    H again Dr. G,

    I have been requested to increase my Quetiapine from 400mg XR to adding 150 mg of non XR for anxiety over the next few days.

    Please could you advise me of what side-effects I should expect and when the medication should take effect.

    Many thanks,

    Carl.
    Reply
     
    avatar
    Joseph F Goldberg, MD responded:
    Dear Carl,

    There is no known difference in the effects of quetiapine XR versus non-XR in known effects regarding mood or anxiety; it is the same drug. The non-XR is thought by some to cause a faster sedating effect than the XR form, otherwise there aren't really known differences in the effect of either the drug on the body. Chances are, the antihistamine effects of the XR are already maximized so I'm not sure a higher dose would necessarily yield much difference in this range unless the target symptoms were psychosis or mania. Doses of quetiapine at 300 mg/day are known to treat depression, though higher doses have not shown a greater antidepressant benefit. Doses in the 400-800 mg/day range are more commonly used to treat psychosis or mania.

    Dr. G.
     
    avatar
    Carl_1970 replied to Joseph F Goldberg, MD's response:
    Hi again Dr.G

    I was prescribed 600mg when I was originally diagnosed as the treatment dose. I remained on this for 2 years before being allowed to reduce it to 500mg over 4 months, then 400mg for 8 months, then 300mg in March this year.

    Due to stress at work, I have had a relapse.

    Please would you advise me as to whether I would be less susceptible to a relapse if I was on a higher dose than the 300 mg?

    Many thanks,

    Carl.
     
    avatar
    Joseph F Goldberg, MD replied to Carl_1970's response:
    Dear Carl, Everyone is different and one size does not fit all, and your doctor is the only one who can make specific treatment recommendations for you. That said, in the studies of relapse prevention with Depakote or lithium plus seroquel or placebo, the average seroquel dose was about 550 mg/day. Dr G
     
    avatar
    Carl_1970 replied to Joseph F Goldberg, MD's response:
    Dr. G,

    Thank you very much for your reply and the information.

    I am only taking Seroquel at the moment, 50 mg in the morning and 550 mg at night as a treatment dose.

    Please would you inform me as to how long it should take for this increased dosage (from 300mg) to have full effects?

    Carl


    Featuring Experts

    Joseph F. Goldberg, MD, is a Clinical Professor of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY. He also maintains a private prac...More

    Helpful Tips

    Differentiating bipolar disorder from borderline personality disorderExpert
    Borderline personality disorder is a condition in which people can very easily become angry and upset in response to stresses -- especially ... More
    Was this Helpful?
    116 of 133 found this helpful

    Related Drug Reviews

    • Drug Name User Reviews

    Report Problems With Your Medications to the FDA

    FDAYou are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.