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Lithium dosage
An_254409 posted:
Dr. G,
I am currently on a maintenance dosage of Lithium Carbonate at 900 mg per day. I also take Invega and Wellbutrin.
Is it possible to take my 900 mg of lithium only once a day - in the morning? (either the regular release or extended release tablets). Based on what my doc says and what I read, it appears it is not ok. But I am missing my evening doses due to school and other reasons - and I'm thinking it would be better to at least get the full 900 mg in in the morning rather than missing the evening dose every once in a while.
Joseph F Goldberg, MD responded:
Dear An, I usually dose most if not all of my patients' lithium as once a day. Once-daily has been shown to carry a lesser risk for lithium-induced kidney problems. The half life of lithium carbonate is 24 hours, so there is really no pharmacologic reason to dose it more often than once a day unless all at once is poorly tolerated. Dr G

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