Find Information About:

Drugs & Supplements

Get information and reviews on prescription drugs, over-the-counter medications, vitamins, and supplements. Search by name or medical condition.

Pill Identifier

Pill Identifier

Having trouble identifying your pills?

Enter the shape, color, or imprint of your prescription or OTC drug. Our pill identification tool will display pictures that you can compare to your pill.

Get Started

My Medicine

Save your medicine, check interactions, sign up for FDA alerts, create family profiles and more.

Get Started

WebMD Health Experts and Community

Talk to health experts and other people like you in WebMD's Communities. It's a safe forum where you can create or participate in support groups and discussions about health topics that interest you.

  • Second Opinion

    Second Opinion

    Read expert perspectives on popular health topics.

  • Community


    Connect with people like you, and get expert guidance on living a healthy life.

Got a health question? Get answers provided by leading organizations, doctors, and experts.

Get Answers

Sign up to receive WebMD's award-winning content delivered to your inbox.

Sign Up


Posting to the communities has been restored. Our technical team is still completing ongoing maintenance, and you may experience some technical problems.Thank you for your continued support and patience, and if you have any further questions, please email

Yours in health,
WebMD Community Management

Visit our Crisis Assistance Link for resources. For immediate help, get to the ER.

*No Dr Outside Contact Please*
Includes Expert Content
Dr. G - Provigil
ddnos posted:
Hi Dr. G.

I take Provigil 200mg as needed - some months I may take it 50-60% of the month, and other months only take it 10% of the time...just saying this so you know I don't take it daily (pertinent to my question)

So I have noticed the past 3-5 times I have taken provigil that it hasns't been as effective as normal. In the past, if I woke up early, I would take a pill and then go back to bed and wake up within 1.5 hrs full of energy and elevated mood. But lately, I will sleep 2-3 hrs after med, and some days even take a 2 hr nap in the afternoon. The whole purpose for me to take this med was so that I don't sleep all day.

The difference between now and before is I'm currently on a lower, non-therapeutic dose of Nardil from trying to wean off it, so have been more depressed (along with some other stress related stuff going on), so could that be the reason why Provigil hasn't been as effective for me lately? To be clear, it still works to a degree, just not as well as it used to. What do you think?

Thank you
Forgiveness is letting go of the hope that the past could have been any different --Unknown
Joseph F Goldberg, MD responded:
Dear Debbie,
It's possible you had been noticing an additive benefit between midafinil and the higher dose of Nardil, which is cumulatively less on the lower Nardil dose. There is no known drug interaction between Nardil and modafinil so it's not a "chemical" interaction effect. Also if you are aware of feeling more depressed, it's possible that a higher modafinil dose taken on a more regular basis would deliver a better effect.

Dr. G.
ddnos replied to Joseph F Goldberg, MD's response:
Thank you, Dr. G., but I'm not sure what you meant when you said, "It's possible you had been noticing an addictive benefit between modafinil and the higher dose of Nardil." I don't understand the use of the word "addictive" in this context because I thought that neither Nardil or Modafinil were addictive? I mean, I know that Nardil isn't, and I thought that Modafinil isn't either? Could you please explain?

Thank you

Forgiveness is letting go of the hope that the past could have been any different --Unknown
Joseph F Goldberg, MD replied to ddnos's response:
Dear Debbie, "Additive," not "addictive." Dr G
ddnos replied to Joseph F Goldberg, MD's response:
Dr. G. lol that's funny because before I replied I even wondered if you said "additive" and not addictive, so I double checked. Well, obviously, my eyes still saw "addictive"......ooops!

Forgiveness is letting go of the hope that the past could have been any different --Unknown

Featuring Experts

Joseph F. Goldberg, MD, is a Clinical Professor of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY. He also maintains a private prac...More

Helpful Tips

Differentiating bipolar disorder from borderline personality disorderExpert
Borderline personality disorder is a condition in which people can very easily become angry and upset in response to stresses -- especially ... More
Was this Helpful?
115 of 132 found this helpful

Related Drug Reviews

  • Drug Name User Reviews

Report Problems With Your Medications to the FDA

FDAYou are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.