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blessed8991 posted:
I had posted earlier about taking BENTROPINE for the side effects of both abilfiy and saphris. So anyway, I did some reseach and found that the bentropine blocks dopamine and dopamine is a GOOD thing!!!!!! No wonder why I feel so down and depressed. I have questions for my doc because she knows I am down and depressed and said NOTHING about this side effect med and the possible connection there. Any thoughts??
Joseph F Goldberg, MD responded:
Dear blessed,
There are several different dopamine pathways in the brain, each doing some different function. In a part of the brain called the mesocortical pathway, dopamine signalling allows for planning, thinking, motivation, attention and reward -- good stuff. In a different part of the brain, called the mesolimbic pathway, excessive dopamine can cause psychosis -- bad stuff. Antipsychotics block dopamine in the mesolimbic pathway and thus treat psychosis. Yet another brain pathway, called the nigrostriatal pathway, controls movements, and this one's a bit more complicated. Antipsychotic drugs that block dopamine in this brain pathway allow the release of another chemical called acetylcholine, and when acetylcholine levels go up in this brain region that controls movement, people can get involuntary muscle movements. Benztropine doesn't block dopamine, it blocks the acetylcholine (it is an "anticholinergic" drug...just like Benadryl) that rises undesirably when antipsychotics block dopamine in the nigrostriatal pathway. Benztropine does nothing that would affect mood or depression one way or another -- any more than Benadryl. Makes sense?

Dr. G.
blessed8991 replied to Joseph F Goldberg, MD's response:
Dear Doc G, Thanks for the time and effort to explain all that...It's makes sense to me now, but I am still looking to downsize some of the meds I take...I think..just like Lithium destroying my thyroid that soooooo many of them are toxic...

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Joseph F. Goldberg, MD, is a Clinical Professor of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY. He also maintains a private prac...More

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