Skip to content


    Exciting News for WebMD Members!

    We've been busy behind the scenes building new message boards for you. You'll have new and easier ways to find messages, connect with others, and share your stories.

    And, this will all be available on your smartphone or other mobile device!

    What Do You Need to Do?

    The message board you're used to will be closing in the coming weeks. While many of your boards will be making the move to our new home, your posts will not. Want to keep a discussion going? Save posts you want to continue (this includes your member profile story), so that you can re-post them in the new message boards.

    Keep an eye here and on your email inbox, we'll be back in touch soon to give you all the information you need!

    Yours in health,
    WebMD Message Boards Management

    Visit our Crisis Assistance Link for resources. For immediate help, get to the ER.

    *No Dr Outside Contact Please*
    Includes Expert Content
    Seroquel and Risperdal question (Dr. G)
    reneegigliotti posted:
    Hi Dr. G

    Can adding Risperdal (2 mg to be later increased to 4 mg) to a medication mixture of Depakote (2000 mg), lithium (1125 mg) and Seroquel (600 mg) improve psychotic depressions and psychotic manias? I always thought they were in the same family of medications. I had gastric bypass surgery 4 years ago so my doses skew high for that reason. I meant to ask my Dr. G the question, but we got onto many other subjects today and it escaped my mind. I thought I'd ask you. Hope it's ok.

    Joseph F Goldberg, MD responded:
    Dear Renee,

    Risperdal has known value for psychosis and mania but hasn't been shown to treat depression symptoms (though it might help other symptoms associated with depression like agitation or anxiety). It is in the same family as Seroquel and is somewhat redundant with it -- kind of like taking Advil plus Aleve -- and both Seroquel and risperidone "compete" for some of the same binding receptors so it's not clear they would enhance each other's effect. Risperidone binds much more tightly than Seroquel does to dopamine receptors so it's possible that risperidone could "kick out" some of the Seroquel from their shared targets, and, if risperidone seemed to be more effective, then the Seroquel might be redundant and perhaps worth reducing. But, there is no harm in mixing them.
    Dr. G.
    reneegigliotti replied to Joseph F Goldberg, MD's response:
    Thanks, I'm not sure what his goal is. He's very careful about prescribing so he's thinking about something. I just don't know what that something is. I should have thought to ask yesterday. You MDs can be so inscrutable sometimes.

    Featuring Experts

    Joseph F. Goldberg, MD, is a Clinical Professor of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY. He also maintains a private prac...More

    Helpful Tips

    Screen out people who can't seem to "get it"....
    There are some people who can't or won't understand at all. My wife is bipolar, and some people are more understanding than others. We ... More
    Was this Helpful?
    37 of 43 found this helpful

    Related Drug Reviews

    • Drug Name User Reviews

    Report Problems With Your Medications to the FDA

    FDAYou are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.