National Bipolar Foundation An age at onset for a first Manic Episode after age 40 year should alert the clinician to the possibility that the symptoms may be due to a general medical condition or substance use. There is some evidence that untreated thyroid disease worsens the prognosis of bipolar I Disorder.
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0 Replies |Report This| Share this:Onset over 40<a rel="nofollow" href="http://www.facebook.com/NationalBipolarFoundation?ref=mf"><b>National Bipolar Foundation</b></a> An age at onset for a first Manic Episode after age 40 year should alert the clinician to the possibility that the symptoms may be due to a general medical condition or substance use. There is some evidence that untreated thyroid disease worsens the prognosis of bipolar I Disorder.