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Drugs to help prevent atypia/breast cancer
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atypia posted:
I have been diagnosed with Atypia Ductal Hyperplasia. I have had three biopsies and surgeries in the last three years to remove the cells. My doctor recommended that I go on Tamoxifin for 5 years to reduce my risk of the cells coming back. I went to see an oncologist even though I do not have cancer and he recommended either tamoxifin or raloxifin. I was still undecided so I went to see another oncologist and he recommended an aromatse inhibitor. Now I am totally confused. I am post menopausal. I want to do what is best for me and it seems like the aromatase inhibitors have the least amount of side effects but I am not sure they will work. Everything I read tells me it will only work on hormone receptor positive breast cancer. From what I understand it is not known whether these atypia cells are negative or positive hormone receptors. I would love to know what other people with reoccurring ADH are doing????
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judyfams responded:
Since estrogen positive bc is very common in women over the age of 50 - it seems that your doctors are going with the prevailinhg statistics in having you do hormone therapy.
You have not been diagnosed with bc - but ADH does put you at greater risk for being diagnosed with bc at some time in the future. Hence the reason for hormone therapy.
Tamoxifrn and aromatase inhibitors are 2 different classes of anti-estrogens and they both have side effects which are very different from one another. Both pre and post menopausal women can take Tamoxifen, aromatase inhibitors are used for post menopausal women.
Tamoxifen belongs to a group of drugs known as SERM's which prevent the estrogen receptors on the surface of cancer cells from letting the estrogen into the cell so the cell can grow and multiply. With Tamoxifen, the body still manufactures estrogen. The side effects could be hot flashes, insominia, weight gain, and the rare more serious side effects of blood clots andthe possibility of endometrial cancer. Most women on Tamoxifen also have a vaginal ultrasound done to check for that.
Aromatase Inhibitors actually block the body from making estrogen, so there is no estrogen in the body. The AI's can also cause hot flashes, insominia and weight gain, vaginal dryness and their more serious side effects are, osteopenia (which can lead to osteoporosis) severe muscle aches and pains.
So they all have side effects and if you do decide to take one of these drugs - I would recommend you speak with your oncologist about the side effects of each drug, and then choose if you want to take an anti estrogen drug, and if so - which drug you want to take.
Please let us know what you decide to do.
Good luck,
Judy


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