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justwan3 posted:
How do Statins remove cholesterol from the body
billh99 responded:
Statins don't remove cholesterol.

While some is absorbed from food, in most people the majority off cholesterol is formed in the liver.

Statins help block an enzyme that makes the cholesterol.

"Statins" are a class of drugs that lower the level of cholesterol in the blood by reducing the production of cholesterol by the liver. Statins block the enzyme in the liver that is responsible for making cholesterol. This enzyme is called hydroxy-methylglutaryl-coenzyme A reductase (HMG-CoA reductase). Scientifically, statins are referred to as HMG-CoA reductase inhibitors.

Statins also reduces inflammation and helps stabilize plaque in the arteries.
oldie28 replied to billh99's response:
'Statins also reduces inflammation and helps stabilize plaque in the arteries?

cardiologists say this too. Who does not mention it at all are the big pharmas who make statins - check it out on the information sheet in the box of tablets or on their websites. If it does this why don't they claim it and broadcast it?.
bobby75703 replied to oldie28's response:
I have heard the claim that statins stabilize plaque, but this claim has always caused me to raise an eyebrow.

How do they substantiate this claim?

I remember one guy who was not happy because he thought the statin he was taking would stop his artery plaque from progressing. Despite taking the statin, plaque continued to grow.
billh99 replied to bobby75703's response:

Pleiotropic effects of a drug are actions other than those for which the agent was specifically developed. These effects may be related or unrelated to the primary mechanism of action of the drug, and they are usually unanticipated. Pleiotropic effects may be undesirable (such as side effects or toxicity), neutral, or, as is especially the case with HMG-CoA reductase inhibitors (statins), beneficial. Pleiotropic effects of statins include improvement of endothelial dysfunction, increased nitric oxide bioavailability, antioxidant properties, inhibition of inflammatory responses, and stabilization of atherosclerotic plaques. These and several other emergent properties could act in concert with the potent low-density lipoprotein cholesterol-lowering effects of statins to exert early as well as lasting cardiovascular protective effects. Understanding the pleiotropic effects of statins is important to optimize their use in treatment and prevention of cardiovascular disease.

Besides the lipid lowering effects, statins have also been shown to modulate the inflammatory status and improve endothelial function amongst others, commonly referred to as "pleiotropic effects". In the present review we will discuss different determinants which lead to plaque vulnerability and subsequently we will expand on the plaque stabilizing or "pleiotropic" effects of statin treatment.

Aims Heat released from atherosclerotic plaques as a result of the local inflammatory process, may be measured in vivo by a thermography catheter. Statins seem to have an antiinflammatory effect which results in plaque stabilization. The aim of this study was to investigate the effect of statins on plaque temperature.

Conclusions Patients on statin treatment produce less heat from the culprit coronary lesion than those not treated. Thus, statins seem to have a favourable effect on heat release from atherosclerotic plaques, and whether this effect has an impact on plaque stabilization needs to be investigated in future studies.

The traditional view of cardiovascular disease held that the degree of stenosis defined high-risk lesions and that removal of cholesterol shrank these lesions and thereby enlarged the lumen. Advances in understanding of the pathophysiology of the acute coronary syndromes refute this view. We now appreciate that vascular biology determines plaque stability and that statins stabilize plaque by favorably altering this biology. They do so chiefly (but probably not exclusively) by cholesterol lowering. In addition to reducing the cholesterol content of plaque, lipid lowering inhibits inflammation, and decreases collagenolytic activity and thrombotic potential. The role of lipid-independent effects remains unclear because many studies used statin concentrations too high to have any clinical relevance. However, data suggest that statin-induced alterations in the function of small G proteins may contribute to the anti-inflammatory and antithrombotic actions of statins in clinical practice.

bobby75703 replied to billh99's response:
Thanks for posting that info Bill.

Maybe one day it will be proven beyond any doubt statins stabilize plaque. Until then its "could, may, seem to, needs to be investigated in future studies, traditional view" .... but no solid conclusions or scientific proof yet.

Is there any solid scientific proof statins stabilize artery plaque without escape clauses?
billh99 replied to bobby75703's response:
Is there any solid scientific proof statins stabilize artery plaque without escape clauses?

I don't think that you will every have that for any human medical condition.

Just too many variables and not ethical to do some of the experiments that would be needed.
bobby75703 replied to billh99's response:
Why would it be unethical to do experiments that would be needed?
Whats wrong with doing periodic ultrasounds of arteries of patients being treated with statins?

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