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Unpublished Drug Trials?
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bobby75703 posted:
One physician claims 50% of all trials go unpublished. Now the following article from BioTechniques claims 1/3 of trials funded by the NIH go unpublished.

Why? Why would anyone not publish trial results? What about cholesterol lowering drugs? Are there any unpublished trials on statins?

The article which asks the question: "Why do 1/3 of clinical trials remain unpublished?"

http://www.biotechniques.com/news/biotechniquesNews/biotechniques-326007.html
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iride6606 responded:
"Why do 1/3 of clinical trials remain unpublished?"

The Article also answers that question;

In the end, the researchers couldn't find out why the studies that were published were. They contemplate that those that weren't published could have come across negative findings, had limited resources, or were not accepted by journals for publication.

The audit trail is a mile wide. NIH records are public and anyone can find the trial results. It is expensive to publish results of a trial and if there were no good reasons to go public or the money runs out, what is lost?

No drug can get FDA approval without a published results of the trial that show a benefit. If a drug was tested and no benefit is found, why do we need to see it? In any case, you can get them, just follow the NIH audit trail and go the the researchers for the results if you can't wait to see the published.

Also, keep in mind that any trial that is managed by a DMSB must report any findings that either do or may cause harm. So I ask, what are we missing out on, a paper showing the trial showed no positive results? Why should anyone rush to publish a result in which they don't intend to proceed for FDA approval?

Much ado about nothing but a good story for those that don't trust the system. It's no different than a patent for a product that fails, should they all be published so we understand why they don't get to market?


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