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Cholesterol linked to tendon damage
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iride6606 posted:
Another case of high cholesterol being linked to damage in the body. This time the tendons;

Several studies, including one by Dr. Abboud and his colleagues looking at cholesterol and rotator cuff tears, have found a positive correlation between hypercholesterolemia and tendon injury. Studies of tendon injuries in people with familial hypercholesterolemia, a genetic disorder that results in extremely high blood cholesterol, have provided evidence that may be relevant to more typical cases of high cholesterol in the general population.
Research on fatty deposits in tendons (xanthomas), which are often associated with familial hypercholesterolemia, also provides details about cholesterol's potential contribution to tendon injury. These fatty lesions increase tendon size and may alter the biomechanics of tendons.
Tendinous xanthomas are accumulations of lipid-laden macrophages (foam cells) in tendons (Fig. 1). These foam cells are immune-system cells that have "consumed" deposits of cholesterol. The composition of tendinous xanthomas is remarkably similar to lesions found in atherosclerotic plaques, which increase the risk of cardiovascular disease. Studies of cholesterol-lowering statins have shown that these drugs, usually prescribed to reduce cardiovascular risk, can reduce the size of tendinous xanthomas in people with familial hypercholesterolemia.


http://www.aaos.org/news/aaosnow/jul10/research1.asp
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bobby75703 responded:
LDL cholesterol is one of the greatest gifts to human health. Demonizing cholesterol is purely profit motivated.
 
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bobby75703 replied to bobby75703's response:
Association between statin therapy and tendon rupture.

http://www.ncbi.nlm.nih.gov/pubmed/19454900
 
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iride6606 replied to bobby75703's response:
Bobby, this is old information, what I posted was new research. I'm just the messanger, only passing along current data on the dangers of cholesterol.
 
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bobby75703 replied to iride6606's response:
Cholesterol is vital to build and repair tissue. This is why there is so much cholesterol in an egg. That's what it takes to build a new chick.

Likewise, the cholesterol our body produces keeps our muscles and tendons in tip top condition.

Demonizing cholesterol is purely for profit.
 
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billh99 replied to bobby75703's response:
http://emedicine.medscape.com/article/121975-overview#showall

Familial hypobetalipoproteinemiaAPOB gene mutationFHBL is a rare autosomal dominant disorder of apoB metabolism. Most cases of known origin result from mutations in the APOB gene, involving 1 or both alleles. More than 30 mutations have been described. Most often, a mutation involving a 4—base—pair deletion in the APOB gene prevents translation of a full-length apoB-100 molecule, leading to the formation of truncated apoB molecules (apoB-37, with 1728 amino acids; apoB-46, with 2057 amino acids; or apoB-31, with 1425 amino acids).[a>[3, 4, 13, 14>
Metabolic turnover studies indicate that in some persons, these APOB gene mutations result in impaired synthesis of apoB-containing lipoproteins, and that in other patients, they cause increased catabolism of these proteins. Overall, beta-lipoprotein levels remain low.
Heterozygotes may have LDL cholesterol levels less than or equal to 50 mg/dL, but they often remain asymptomatic and have normal life spans.
 
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iride6606 replied to billh99's response:
This post has nothing to do with how much yolk is in an egg or how much cholesterol is in a yoke or chickens. This is about excess cholesterol and what it does. There are some here that say cholesterol is a natural thing, every body needs it. But what if we have more than our body needs?

So here it is, excess cholesterol depositing on tendons and around the eyes. It also collects in the joints and under the skin. These pics represent the natural result of having too much. Let me ask, does this look natural or normal to anyone? Does anyone here want this much cholesterol in them? I think not, after all if it can collect like this, why would anyone believe it can't happen in the arteries?








And here it is when it deposits around your eyes;





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