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New Website: Number Needed to Treat
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bobby75703 posted:
TheNNT.com is a recent website that explains in simple language, when taking a drug, how many people benefit and how many people are harmed.

This site was pointed out to me today by a Cardiologist.

So lets look at statin drugs.

First category: Statin drugs given for 5 years (without known heart disease) http://www.thennt.com/nnt/statins-for-heart-disease-prevention-without-prior-heart-disease/

Second category: Statins given for 5 years ( with known heart disease) http://www.thennt.com/nnt/statins-for-heart-disease-prevention-with-known-heart-disease/
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iride6606 responded:
Hmmm, you may be confused This is a perfect example of why we need to read the source data and not just the headlines. It took the better part of the first half but I enjoyed reading it all.

This article is about the over use of NNT's, from the source data;

INTERPRETATION: Statin therapy is associated with a slightly increased risk of development of diabetes, but the risk is low both in absolute terms and when compared with the reduction in coronary events. Clinical practice in patients with moderate or high cardiovascular risk or existing cardiovascular disease should not change.And;
AUTHORS' CONCLUSIONS: Reductions in all-cause mortality, major vascular events and revascularisations were found with no excess of adverse events among people without evidence of CVD treated with statins.
And;

CONCLUSIONS: Statins have a clear role in primary prevention of CVD mortality and major events.
And;
CONCLUSION: In patients without established cardiovascular disease but with cardiovascular risk factors, statin use was associated with significantly improved survival and large reductions in the risk of major cardiovascular events.And;

INTERPRETATION: Statin therapy can safely reduce the 5-year incidence of major coronary events, coronary revascularisation, and stroke by about one fifth per mmol/L reduction in LDL cholesterol, largely irrespective of the initial lipid profile or other presenting characteristics. The absolute benefit relates chiefly to an individual's absolute risk of such events and to the absolute reduction in LDL cholesterol achieved. These findings reinforce the need to consider prolonged statin treatment with substantial LDL cholesterol reductions in all patients at high risk of any type of major vascular event.And;
CONCLUSIONS: In this trial of apparently healthy persons without hyperlipidemia but with elevated high-sensitivity C-reactive protein levels, rosuvastatin significantly reduced the incidence of major cardiovascular events. (ClinicalTrials.gov number, NCT00239681.)Not sure that Cardiologist explained this to you very well or perhaps you misunderstood his meaning. Back to the football game.


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