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    FDA Questioning New Cholesterol Drugs for Cognitive Issues.
    avatar
    bobby75703 posted:
    FDA Sprinkles Some Rain On the PCSK9 Inhibitor Parade
    Fresh today from Forbes:
    http://www.forbes.com/sites/larryhusten/2014/03/07/fda-sprinkles-some-rain-on-the-pcsk9-inhibitor-parade/
    Reply
     
    avatar
    iride6606 responded:
    People should take statins instead I guess
     
    avatar
    bobby75703 responded:
    The brain is very dependent upon cholesterol. Inhibiting cholesterol with PCSK9 or statins, either way, bears the potential to impair cognitive function.
     
    avatar
    iride6606 replied to bobby75703's response:
    No, excess cholesterol causes a breakdown in brain function (entire article actually posted);


    In conclusion, AD and NPC1 exhibit cell cycle abnormalities, to which excess lipoproteins, particularly LDL, can contribute and lead to the chromosome mis-segregation, aneuploidy and neurodegeneration observed in these diseases. Furthermore, the fact that aneuploid neurons also characterize other cognitive brain diseases, such as Frontotemporal Dementia [97> (also Granic et al., unpublished), Down syndrome and Ataxia-Telangiectasia [20> , suggests that chromosome mis-segregation and the development of aneuploidy neurons may be a general feature of neurodegeneration.


    I know, it's bit technical, but if l can help, just ask.


    http://www.plosone.org/article/info:doi/10.1371/journal.pone.0060718
     
    avatar
    bobby75703 replied to iride6606's response:
    Cholesterol plays a vital role in brain function.
     
    avatar
    bobby75703 replied to bobby75703's response:
    Cholesterol plays a vital role in nerve function.
     
    avatar
    iride6606 replied to bobby75703's response:
    Cholesterol levels linked to brain deposits that cause Alzheimer's


    http://www.medicalnewstoday.com/articles/270710.php


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