Skip to content


    Exciting News for WebMD Members!

    We've been busy behind the scenes building new message boards for you. You'll have new and easier ways to find messages, connect with others, and share your stories.

    And, this will all be available on your smartphone or other mobile device!

    What Do You Need to Do?

    The message board you're used to will be closing in the coming weeks. While many of your boards will be making the move to our new home, your posts will not. Want to keep a discussion going? Save posts you want to continue (this includes your member profile story), so that you can re-post them in the new message boards.

    Keep an eye here and on your email inbox, we'll be back in touch soon to give you all the information you need!

    Yours in health,
    WebMD Message Boards Management

    High Cholesterol - Can't take a Statin?
    An_188243 posted:
    I have very high Cholesterol from genetics - 320 total. I tried two different statins and both elevated my liver enzymes. Diet and Exercise was NOT enough to lower it.

    My Doctor then tried me on Fenofibrate and it lowered my Triglycerides by 300 points with out ANY issues with the liver with in 4 weeks.
    I'm still waiting on total Cholesterol level results, but you may want to ask your Doctor about Fenofibrate if you can't take a statin.
    Was this Helpful?
    6 of 10 found this helpful
    toneman84084 responded:
    I've been taking Simvastatin along with a Fenofibrate (Tricor) for years, it's a very good drug which works by helping to breakdown fats in your digestive system.

    Although they work best of serum TGL's they have been shown to lower LDL in excess of 10% when used along with diet and exercise. The one exception is for people with very high serum TGL's, where they may actually cause an increase in LDL. From the manufacturer;

    Fenofibrate can actually cause an increase in LDL cholesterol for people with very high levels of triglycerides (greater than 350 mg/dL). Therefore, the medication should be used with extreme caution or not at all for people with this condition who also have high levels of LDL cholesterol.

    Let us know how your numbers turn out.


    Featuring Experts

    There are no Expert stories for this community right now

    Helpful Tips

    Statin use is generally safe, and NOT associated with cancer and myopathy
    This network meta-analysis study provides evidence on the comparative tolerability and harms of individual statins. Overall, statins as a ... More
    Was this Helpful?
    1 of 2 found this helpful

    Helpful Resources

    Be the first to post a Resource!

    Related Drug Reviews

    • Drug Name User Reviews

    Report Problems With Your Medications to the FDA

    FDAYou are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.