Skip to content

    Announcements

    Exciting News for WebMD Members!

    We've been busy behind the scenes building new message boards for you. You'll have new and easier ways to find messages, connect with others, and share your stories.

    And, this will all be available on your smartphone or other mobile device!

    What Do You Need to Do?

    The message board you're used to will be closing in the coming weeks. While many of your boards will be making the move to our new home, your posts will not. Want to keep a discussion going? Save posts you want to continue (this includes your member profile story), so that you can re-post them in the new message boards.

    Keep an eye here and on your email inbox, we'll be back in touch soon to give you all the information you need!


    Yours in health,
    WebMD Message Boards Management

    Portfolio Diet lowers LDL as well as statin, BUT ...
    avatar
    billh99 posted:
    http://www.berkeleywellnessalerts.com/alerts/healthy_heart/portfolio-diet318-1.html?ET=bwalerts:e1012:123630a:&st=email&s=EHA_110809_001

    But there is no proof that if it lowers heart attacks. Statins also have several other effects beside lowering cholesterol. They are stabilizing plaque and reducing inflammation.

    Also, according the article, it is difficult diet to follow long term.
    Was this Helpful?
    3 of 5 found this helpful
    Reply
     
    avatar
    bobby75703 responded:
    "But there is no proof that if it lowers heart attacks."


    That is the ultimate outcome. Does something prevent heart attacks and save lives?


    Its a tough question because its so difficult to measure. When comparing two groups, we can compare the number of heart attacks in each group, but we really don't know who was destined to have a heart attack and who wasn't. Its difficult to measure how any treatment may have avoided an event in any individual.


    Bill, they say statins stabilize plaque. Where does that data come from? What do they mean by stabilize?


    Bobby
     
    avatar
    billh99 replied to bobby75703's response:
    http://www.medscape.com/viewarticle/504394_4

    "
    Plaque Stabilization and Decreased Plaque ThrombogenicityExperiments have demonstrated that cholesterol reduction is accompanied by favorable alterations in a number of mediators of plaque stability.[a title="Link: undefined">[39,40> Studies have shown that statins decrease macrophage number, reduce expression of tissue factor, adhesion molecules, and matrix metalloproteinases within plaque.[a title="Link: undefined">[39> The 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors also reduce the oxidation of LDL, macrophage uptake of LDL,[a title="Link: undefined">[24,25> and reduce monocyte adhesion to endothelium.[a title="Link: undefined">[25> Lipid lowering with statins results in increased smooth-muscle cell content (a surrogate of plaque stability) and decreased collagen degradation (which may further enhance plaque stability).[a title="Link: undefined">[39> Clinical studies support these experimental observations and provide further evidence that statin therapy may be associated with plaque stabilization. Statins may also inhibit atherogenesis through the inhibition of vascular smooth-muscle cell proliferation and migration, and thus attenuate plaque growth and new lesion formation.[a title="Link: undefined">[41>
    Another factor which may contribute toward decreased risk for stroke with statin therapy is the effect of statins on platelets and the endogenous balance of thrombosis/thrombolysis.[a title="Link: undefined">[40> Statin therapy decreases platelet activation and aggregation, and thereby may decrease the propensity toward thrombosis.[a title="Link: undefined">[10,23,42,43> Statin therapy inhibits tissue factor expression by macrophages, which plays an integral role in blood coagulation and is an important determinant of plaque thrombogenicity.[a title="Link: undefined">[23,25> There also may be a reduction in plasminogen activator inhibitor activity, which would facilitate fibrinolysis.[a title="Link: undefined">[23> All of these factors may contribute toward decreased risk for stroke seen in the statin studies. These statin effects may lead to decreased thrombus formation and thereby influence the development of clinical activity related to atherosclerotic plaque."


    I think that the basic information comes from lab studies (animals?) Then in limited clinical studies they look for some of the same biological markers that they saw in the animals.


    I am mostly speculating on this, because I don't want to have to run down all of the references.


    http://content.onlinejacc.org/cgi/content/full/49/2/271


    Atherosclerosis Regression, Vascular Remodeling, and Plaque Stabilization[a title="Link: undefined" name="RFN1"> *
    http://health.usnews.com/usnews/health/articles/040322/22healy.htm

    Meet the cholesterol busters
     
    avatar
    bobby75703 replied to billh99's response:
    Thank you Bill. I now have clearer picture of what thy mean by the word stabilize.

    I did read the Medscape article and noticed the conclusions were all "may" do this and "may" do that.

    The more i think about it, I guess what I am looking for is conclusive evidence statins stop the growth or prevent rupturing of artery plaque, from an independent unbiased study.

    Does such a thing exists?
     
    avatar
    billh99 replied to bobby75703's response:
    The more i think about it, I guess what I am looking for is conclusive evidence statins stop the growth or prevent rupturing of artery plaque, from an independent unbiased study.

    Not that I know of.

    And I can almost guarantee that there won't be any such thing.

    Other than a few basic things, such as you need to stop bleeding, you will never find it in medicine.

    There is just too wide a variation of people.

    And much of this comes from experiements that could not be done on humans.


    Featuring Experts

    There are no Expert stories for this community right now

    Helpful Tips

    Statin use is generally safe, and NOT associated with cancer and myopathy
    This network meta-analysis study provides evidence on the comparative tolerability and harms of individual statins. Overall, statins as a ... More
    Was this Helpful?
    1 of 2 found this helpful

    Helpful Resources

    Be the first to post a Resource!

    Related Drug Reviews

    • Drug Name User Reviews

    Report Problems With Your Medications to the FDA

    FDAYou are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.