Skip to content
Possible Interaction Between Mesalamine and SSRIs?
ericjames posted:
I am newly diagnosed with ulcerative colitis in my rectum and sigmoid colon. My GI doctor prescribed Lialda 4.8 g daily plus mesalamine enemas at night. I also take Effexor XR 225 mg daily for my anxiety and depression which I have been on for many years. Since starting the new meds I seem to be more fatigued, lightheaded/dizzy, weak and slightly more anxious than usual. I'm not sure if this could be a side effect from the Lialda combined with Effexor. Is anybody else taking antidepressants with mesalamine and noticed this effect? It's difficult to tell right now if I feel this way from the meds or my anemia secondary to UC. I take 65 mg iron supplement plus multivitamin with iron for that as well.
hannahleigh89 responded:
I am not sure if the two are reacting or not. I will do some research and try to find you answers but unfortunately, I don't know that it will do any good. All medications affect each person differently, as I'm sure you've heard a thousand times. Is there a reason your doctor opted to go with enemas instead of oral medications? Or were they just thinking that since it was farther down in your GI tract, you would respond better to enemas? I've never had any experience with those.

From doing a quick Google search, I can't seem to really find anything that would indicate there is a known interaction. I'm away from home so I don't have any of my drug books with me. The page does indicate that Lialda can cause nervousness, dizziness, and fatigue.

I would say that it could certainly be from the anemia- it can take a while for iron supplements to kick in and get your blood counts back to normal, especially if you are still losing blood. I would suggest calling your doc, obviously, because I'm a nurse and that's what I've been trained to say when I don't have a definitive answer.

I'm on a multitude of meds and I struggle with fatigue and weakness on a daily basis. I know mine is from malnutrition and dehydration, a long with not getting a restful night of sleep. I also have issues with anemia. How recently were you diagnosed?

I apologize that it's taken me a while to respond to your post- I recently reformatted my desktop and couldn't find this page again until I broke out the laptop, lol. Hope you've found some answers by now.

Spotlight: Member Stories

March 24th of 2009, I started undergoing immediate treatment for Crohn's Disease. My symptoms began 6 years ago. It hurt to eat food, I would rapi...More

Helpful Tips

Assistance for Medical Expenses
Many with a diagnosis of Crohn's or Colitis are unable to work or enjoy many social or physical activities. The burden of paying medical ... More
Was this Helpful?
22 of 28 found this helpful

Report Problems With Your Medications to the FDA

FDAYou are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.