See All
Preferences
My Communities
My Discussions
My Email Digests
Announcements
What is a Trigger and When to Trigger a Post
How and Why to Report a Post
Visit our Crisis Assistance Link for resources. For immediate help, call 911 or get to the ER.
Just 2 weeks ago, a new review called "Efficacy and Effectiveness of Antidepressants " by H. Pigott et al. was published in Psychotherapy and Psychosomatics. It involved four meta-analyses of efficacy trials submitted to the FDA and suggested that ADMs are only "marginally efficacious" compared with placebo, showing "a sustained benefit only 2.7% above placebo."
The Emperor's New Drugs: Exploding the Antidepressant Myth, by Irving Kirsch, Ph.D., is a new book providing a detailed accounting of the huge controversy he sparked by suing to obtain the hidden data about antidepressant medications. Kirsch created an uproar when he added back in the negative data the drug companies had hidden from view while shamelessly promoting drugs they knew were little better than placebos. Kirsch was interviewed by Newsweek magazine in the February 8th issue (see the lead article "The Depressing News About Antidepressants " by Sharon Begley). This was the first time the general public was alerted to the issues raised by Kirsch and many others who also revealed the misdeeds of BigPharm.
When so many people rely on these medications, experts don't take it lightly to raise questions about them. No one who devotes their career to studying depression and who wants to help people seeks to undermine a potential solution. But, it has become increasingly apparent over the years that the promise of antidepressants has become a marketing tool more than a genuinely effective treatment. Just taking medications is not likely to be enough of an intervention for most people. The importance of learning specific skills known to reduce - and even prevent - depression is more apparent than ever and will be the subject of future blogs.
It is vitally important to be realistic about what medications can and cannot do in helping people overcome depression. When you hear about new research like this, does it affect your views about antidepressants?
Take the Poll
- No, not at all
- Yes it does
- No opinion

Poll Results
-
No, not at all42% (8)
-
Yes it does53% (10)
-
No opinion5% (1)
I know I am on my 3rd week on Elavil and I think I am starting to feel better. Its a battle though, but I am trying my very best and am also talking with a Therapist. But still, this is somewhat discouraging news to me.
I already had that antidepressants are little more than placebos.
It's so frustrating that we can do heart transplants,
and eye surgery, and other miraculous medical procedures,
but so far, there's basically nothing for those of us
stuck in the black hole of depression.
i was appalled when i read the newsweek article, because i have plenty of experience on/off depressants, and on/off different antidepressants, and
-- i know for certain that i would be dead if it were not for antidepressants, and
-- it makes me afraid that people who might benefit from them will not even try them.
-- susie margaret
Without the help of medication and a good dr I think I would not be here now to post on this thread.
x
here are some resources for finding free/low-cost meds --
-- ask your prescribing dr or your family dr for samples;
-- ask a pharmacist if s/he knows of local/state/national programs for getting free/low-cost meds;
-- ask a pharmacist if any of the meds you are taking have generic equivalents, which are much less expensive than brand-name ones; many discount stores (target, wal-mart, etc.) and grocery store pharmacies dispense generic meds at $4/month;
-- look at the labels on your current meds, get the manufacturer's name for each, then apply to each manufacturer's patient assistance program;
-- check out the listings from these websites -- http://www.pparx.org/prescription_assistance_programs , http://www.needymeds.org/indices/pap.shtml , http://www.rxoutreach.com , http://www.gskforyou.com/10_programs.htm , and http://www.211.org ;
-- check out the website for the national conference of state legislatures, which lists prescription assistance programs by state (subsidy programs, table 1, and discount programs, table 2, each can be reached by a link within the text); the page with the listings requires a little maneuvering but is well worth the effort -- http://www.ncsl.org/IssuesResearch/Health/StatePharmaceuticalAssistanceProgramsNCSL200/tabid/14334/Default.aspx#Discount ;
-- check out these websites to determine your eligibility for various govt assistance programs -- https://www.benefitscheckup.org/index.cfm?partner_id=0 , and http://www.govbenefits.gov/govbenefits_en.portal?_nfpb=true&_pageLabel=gbcc_page_home&_nfls=false ;
-- check out the NIH website for links to possible sources of financial assistance, http://www.genome.gov/11008842 ;
-- call your city, county, or state dept of health and dept of family services (or something that sounds equivalent), and ask if there are state or local programs for prescription assistance;
-- go to the website for your state government, e.g., http://www.your_state.gov , and click on every social services link you can find; and
-- ask around at food banks, shelters, united way and other charitable organizations, the YMCA/YWCA, and similar places about local programs thru churches, fraternal organizations, etc.
if any of these links do not work or are too hard to navigate, please let me know so that i can correct them or drop them from my list. thanks.
-- susie margaret
Even though antidepressants have helped some peope, there are problems with them that need to be acknowledged and, hopefully, eventually resolved. Some of those problems will not be possible to resolve, though; addressing the social and psychological factors in depression can't be accomplished with a medication. It's the wrong tool for the job.
One of the most important concerns I have is that people are led to believe depression is all about a biochemical issue that only the drug will address. As I've stated, there are many contributing factors to depression, many of which are not biological.
Depression is built on a foundation of passivity; too often, people don't take the steps needed to truly help themselves, believing hopelessly their effort wil be wasted. Just telling someone to take a drug without also advising the importance of actively learning specific skills to help cope and also reduce one's vulnerabilities to depression is what I take issue with. A doctor can unintentionally reinforce passivity by indirectly suggesting to the patient, "you don't need to learn anything new or do anything differently, all you need to do is take the drug on time." This is a likely contributor to depression's higher rate of relapse when all someone does is a take medication compared to when they also enter structured skill-building psychotherapies.
Antidepressants can help, but there are many other approaches, including physical exercise and skill building psychotherapies, that match and even exceed the success rates of antidepressants. Instead of people believing it's all about drugs and biochemistry, I hope to promote a more multi-dimensional view through my postings.Treating a problem with a huge social component on an individual basis with drugs alone assures the problem will continue to grow, just as it is now.
Thanks again for your feedback.
Michael D. Yapko, Ph.D.
I would like to ask your permission to copy your two personal posts on Anti Depressant effectiveness to post onto another exchange board here on WebMD (that exchange was created and is moderated by WebMD staff and also has an expert Dr. there)
I think they could be of assistance and of much interest to many of the people on that board as well. I would of course note that these are your thoughts/posts and credit them to you.
Some of the moderators here (including Caprice) know me and I hope would vouch for my integrity, in the use of your posts and your knowledge regarding these issues.
I will not do anything until I have your permission in writing, and should you decline to allow me to use them, I understand completely and thank you for your information regarding AD now information.
(Caprice, I think your one of the Mods here....) I am not sure if this will comply with the copy write laws on WebMD please tell me if they don't. I think Chrissy's board might be interested in this
.... thanks)Snowy
i respect your view, of course, but who ever said that taking antidepressants was the whole answer? i don't believe i've ever seen anyone in the webMD communities say that, and i hope i don't ever see anyone in the webMD communities say that, i think it would be irresponsible.
what i believe -- and i and others have expressed it over and over -- is that antidepressants do help some people think more clearly so that they can address their problems without so much ambient static in the air. i do believe that with some people, biochemistry is a huge part of the problem and that to that extent, all the psychotherapy in the world won't help. but with many others, yes, behavioral or perspective changes are a good goal to work toward, and psychotherapy can help facilitate those.
i'm afraid that i'm sounding abrupt or intolerant, i hope not. however, because of my own experience, this is something i feel strongly about, and i hope you can understand that.
-- susie margaret
I'm with you a 100%. I know that when I was really sick, all the cognitive behavioural therapy in the world would not have helped if I had not taken antidepressants.
I'm also beginning to see that my lack of real coping skills make me more vulnerable to repeated episodes of depression
The pills seem like an easy answer and, in that sense, they are utterly misleading. My personal truth is that arming myself against depression through the kind of changes in perspective you talk about is my real challenge and solution. I want to eventually wean myself off the drugs. But it's going to take a long time.
Since it's all on WebMD, no matter on which board, there wouldn't be any copyright issues involved by posting this on another of our communities.
However, it might be better, considering this is a good discussion with different viewpoints, to share the web address instead, letting others elsewhere know to come here and read and discuss:
http://forums.webmd.com/3/depression-exchange/forum/5737/

Dr. Yapko
More from WebMD related to this Discussion
See Related Mental Health Communities
Women's Health Newsletter
Find out what women really need.
Featuring Experts
Helpful Tips
Helpful Resources
Related News
Related Drug Reviews
- Drug Name User Reviews
Report Problems to the
Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Other Depression Information
- Depression Health Center
- Families of Depressed & Bipolar Kids Tips and Support from Members Like You!
- Video – Genetic Link to Depression?
-
More Related Communities
The opinions expressed in WebMD User-generated content areas like communities, reviews, ratings, or blogs are solely those of the User, who may or may not have medical or scientific training. These opinions do not represent the opinions of WebMD. User-generated content areas are not reviewed by a WebMD physician or any member of the WebMD editorial staff for accuracy, balance, objectivity, or any other reason except for compliance with our Terms and Conditions. Some of these opinions may contain information about treatments or uses of drug products that have not been approved by the U.S. Food and Drug Administration. WebMD does not endorse any specific product, service, or treatment.
Do not consider WebMD User-generated content as medical advice. Never delay or disregard seeking professional medical advice from your doctor or other qualified healthcare provider because of something you have read on WebMD. You should always speak with your doctor before you start, stop, or change any prescribed part of your care plan or treatment. WebMD understands that reading individual, real-life experiences can be a helpful resource, but it is never a substitute for professional medical advice, diagnosis, or treatment from a qualified health care provider. If you think you may have a medical emergency, call your doctor or dial 911 immediately.
Health Solutions From Our Sponsors
©2005-2013 WebMD, LLC. All rights reserved.
WebMD does not provide medical advice, diagnosis or treatment. See additional information.


