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    Includes Expert Content
    Effectiveness of antidepressants over time
    An_245828 posted:
    I've been taking Wellbutrin for about four years, and am up to two 200mg a day. Recently I've been feeling horrible - sometimes worse than before I started taking it. I started wondering if maybe I've been taking it too long and my body has kind of built up a resistance to it, or maybe my dosage is too high and has lost its effectiveness. I'm also taking 40mg of Adderall, and my doctor once told me that taking too much can have the opposite effect, so I started wondering if maybe that was the case. Does that happen with antidepressants?
    Thomas L Schwartz, MD responded:
    yes, sometimes the medicines can wear off and stop working. Sometimes, the depression etc, can build up and overhwhelm the medicine... So, sometimes doses are increased or medicine changed

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