Skip to content


    Exciting News for WebMD Members!

    We've been busy behind the scenes building new message boards for you. You'll have new and easier ways to find messages, connect with others, and share your stories.

    And, this will all be available on your smartphone or other mobile device!

    What Do You Need to Do?

    The message board you're used to will be closing in the coming weeks. While many of your boards will be making the move to our new home, your posts will not. Want to keep a discussion going? Save posts you want to continue (this includes your member profile story), so that you can re-post them in the new message boards.

    Keep an eye here and on your email inbox, we'll be back in touch soon to give you all the information you need!

    Yours in health,
    WebMD Message Boards Management

    Please take some time to click through these links to find out more about our community.

    What is a Trigger and When to Trigger a Post
    How and Why to Report a Post
    Visit our Crisis Assistance Link for resources. For immediate help, call 911 or get to the ER.

    Deplin help or advice
    Artemisia22 posted:
    Hi. I've been severely depressed for the past year and a half and have been trying different meds and dosages. Last week doctor prescribed Deplin (to take with Wellbutrin XL 450mg and Sam-E 800mg per day -- wasn't working).

    Having taken Deplin for only a few days, I went from crying and sleeping all the time to agitated, aggressive, energized, can't sleep, with mood swings going from anger to abject despair within minutes. Have called my doctor, but am waiting to hear from her.

    Does anyone have experience with this? It's freaking me out a bit. Is this a sign that Deplin is doing its job and I need to lower antidepressant dose? Or is this an adverse reaction?

    Please help!
    Artemisia22 responded:
    UPDATE: this nightmare was due to me misunderstanding my doctor and quitting my Effexor. Even just missing 4 days of it brought on all this craziness and inexplicable rage. Back on the Effexor and by day 2 it all went away. So scary. Would have been nice to be told/warned about Effexor withdrawals BEFORE I started taking it.

    Helpful Tips

    Sexual Problems from Meds..What to do!Expert
    Serotonin type antidepressants can cause 5-30% of the time- sexual problems such as no orgasm, impotence, no libido. Consider that ... More
    Was this Helpful?
    30 of 41 found this helpful

    Related Drug Reviews

    • Drug Name User Reviews

    Report Problems With Your Medications to the FDA

    FDAYou are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.