Skip to content
My WebMD Sign In, Sign Up

Announcements

Please take some time to click through these links to find out more about our community.

What is a Trigger and When to Trigger a Post
How and Why to Report a Post
Visit our Crisis Assistance Link for resources. For immediate help, call 911 or get to the ER.


Deplin help or advice
avatar
Artemisia22 posted:
Hi. I've been severely depressed for the past year and a half and have been trying different meds and dosages. Last week doctor prescribed Deplin (to take with Wellbutrin XL 450mg and Sam-E 800mg per day -- wasn't working).

Having taken Deplin for only a few days, I went from crying and sleeping all the time to agitated, aggressive, energized, can't sleep, with mood swings going from anger to abject despair within minutes. Have called my doctor, but am waiting to hear from her.

Does anyone have experience with this? It's freaking me out a bit. Is this a sign that Deplin is doing its job and I need to lower antidepressant dose? Or is this an adverse reaction?

Please help!
Reply
 
avatar
Artemisia22 responded:
UPDATE: this nightmare was due to me misunderstanding my doctor and quitting my Effexor. Even just missing 4 days of it brought on all this craziness and inexplicable rage. Back on the Effexor and by day 2 it all went away. So scary. Would have been nice to be told/warned about Effexor withdrawals BEFORE I started taking it.


Featuring Experts

Thomas L. Schwartz, MD, received his medical degree from and completed his residency in adult psychiatry at the State University of New York (SUNY) Up...More

Helpful Tips

Ways to help depression
I thought I'd make a little list of things that have helped me, so we can all add to it and help each other. Who knows what we may find, if ... More
Was this Helpful?
27 of 28 found this helpful

Related News

There was an error with this newsfeed

Related Drug Reviews

  • Drug Name User Reviews

Report Problems With Your Medications to the FDA

FDAYou are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.