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    Genetics and Depression
    Thomas L Schwartz, MD posted:
    1. Depression may be inherited from family members. The more family you have that are depressed, the more likely you will be. Perhaps genetics is to blame for about 30% of depression where stress, family upbringing, trauma and personality style is the other 70%.

    2. You may inherit genes for can also inherit the ability to respond to certain medicines that other family members respond too. So, if your dad responded well to prozac, your chances are good too as you likely have the same type of 'genetic' depression which was reversed by prozac in your dad. Doctors should ask you if you have had a family history of depression AND what meds your family took and their response to it
    Was this Helpful?
    48 of 82 found this helpful
    Applepies responded:
    There is depression on both sides of my family. A maternal great uncle committed suicide. A paternal relative committed suicide. My Mother, her sister both have suffered depression. Also their Mother had depression too.
    Shock treatments helped the paternal Aunt for a long time. In later life she was on Prozac, not real effective.
    I had shock treatments, they did not help.
    lissmeanstrouble replied to Applepies's response:
    all my moms brothers and sister are all depressed (family of 7 kids), pretty sure my grandpa was before he died of cancer... I think I get the depressed stuff from my maternal grandpa. My mom is in big denial over it, I wish she would get help. My dad on the other hand was taking wellbutrin to quit smoking, and he is a happy guy, not one bit depressed, and the wellbutrin made him depressed, so he quit taking it. I dont think its very smart to put completely happy people on an antidepressant just to cease smoking.... if anything some one should shove antidepressants down my mothers throat and leave my old daddy alone. I think if my mom started smoking it would chill her out a little bit. shoot dang.
    teawithme responded:
    1. Which genes have been identified as involved in susceptibility to depression? Is it possible to screen for these genes, so that people know if they have a genetic predisposition to depression?

    I'd find it helpful to read the research on this.

    Are geneticists yet comfortable in separating genetic predisposition from environmental factors? How are they doing this? Are identical twin or twin studies available on this?

    Again, the research would be very helpful to me.

    2. Can you point me to the studies that indicate that family members tend to respond to the same medications?

    This would be really helpful to me in sorting out familial responses to medication.

    I'd really appreciate an answer.
    An_202975 responded:
    Doesn't sexual abuse run in families also? Is there a gene for that? Probably not since millions of years of evolution have formed much of our behavior and it seems like if that were true those families would not have evolved. Doesn't the same diet also run in families? Could it be simply a problem with diet like people not eating enough fish? Doesn't lack of exercise also run in families? Doesn't the same religion run in families? Is there a gene for being a Catholic or Protestant or a Jew? By your logic, the more family members I have that are Catholic the more likely I am to be Catholic therefore there must be a gene causing me to be Catholic. Preposterous logic and it clearly shows your bias and the drug companies bias. Who paid for these studies? Like teawithme said, "do they have identical split twin studies or have they identified the gene?"
    tsharp1910 replied to teawithme's response:
    yea its cool that u can help others

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