See All
Preferences
My Communities
My Discussions
My Email Digests
A warm welcome to our newbies that have recently joined our family, and miss a few that were chased away this past year.
PLEASE.. try and be considerate of others, a few here are very sensitive or have other issues that may make things that seem easy to most, especially hard hard for them. Often times these special people NEED this support family most!
Never hurts to follow the Golden Rule or refrain from picking on the sensitive ones who may have handicaps.
Sometimes replies here get lost in cyberspace, when that happens the context of a thread may get changed or lost.
Beta-Q.... Some diabetics are at increased risks to lactic acidosis, if they are metformin (or equiv) the risk increases even if not lactose intolerant. In rare cases it can become serious.
How was YOUR week?
I had my PM&R apt last Fri, told the leg pain was from the tumor pressing on nerves. Also did my labs last week, generally good, a1c improved a little to 5.8, but my annual is now moved up a couple weeks to next week. New neck cooling device came Sat (for the MS)
What's this week look like for YOU?
Just routine foot doc later today, otherwise should be a quiet week.
Gomer .......Tough as nails & rhino tough hide
I'm lucky to have a daughter who has had experience in home health care, and will stay with me. (She has also had a THA, thanks to a broad-side by a driver who ran a red light.)
This time next week, I expect to be totally bored and ready to scream!
I have my last physical therapy today to wrap up my lymphedema self-massage training. And on Wednesday I have my 4th of 8 chemo treatments. It's the last Adriamycin/Cytoxan infusion which is supposed to be the hardest part. After this treatment I'll have 4 Taxol treatments. Taxol is said to be much easier, but there is a greater risk of neuropathy, so I'll be discussing the use of a couple of supplements that are said to help reduce the risk.
I have written a blog entry that I think sums up my philosophy about living life with cancer and diabetes. You might find it interesting, I hope it helps to inspire you to live every day to the fullest.
www.mch-breastcancer.blogspot.com
Have a great week, everyone!
Michelle
This week will be more wound care, time with granddaughter, kayaking/biking if the heat breaks, and exercise. I am going to pick up a UFC fight trainer for the X-box as my niece wants to do it with me online. Should be fun, and be good for the coming months-WINTER
.I just got back on this morning after calling Verizon. They said they could see my internet readings going up and down. I'll have to call them again when I get back, as it will continue to happen.
I'm going to be gone for two weeks. I'll be thinking of all of you.
Newsmom, good luck on your hip replacement. A friend of mine just went through that months ago and is doing GREAT, without pain, too.
Betaquartz, just enjoy those moments in your kayak and your new game!
Everyone else, have a great two weeks!!!
You're doing so great!
And betaquartz, I do not drink regular milk but soy milk instead, and I love cheeses too. The coming week I will have to devote to figuring out what was wrong with me now. Thanks in advance for any help I can get.
Kieu
And fun to put a face with your name and flower
Have you posted in Breast Cancer community? (I have not made my way there yet)
Thank you so much for sharing!
Haylen
)Michelle
Beta - WOW! Can't wait to hear your progress. We got the Wii Fit for Christmas and it is covered in dust - you've inspired me to dust it off!
Consumption of lactose is not related to lactic acidosis. Lactic acidosis occurs when oxygen supplies do not meet the demand.
There are two main processes that produce ATP, which is the direct source of energy for cellular processes (think, "ATP = energy"). One is glycolysis, and this produces two pyruvate molecules and 2 ATP per glucose molecule. Glycolysis occurs outside of the mitochondria, in the cytosol (intracellular fluid) of cells. Then, pyruvate enters the citric acid cycle (AKA Krebs cycle) in a mitochondrion, and lots of ATP is produced (something like 30 ATPs are produced for every two molecules of pyruvate). Thus, as you can see, the mitochondria are very important.
The citric acid cycle is an aerobic process--it requires oxygen. Glycolysis, however, is an anaerobic process. Therefore, when oxygen intake is low and energy expenditure is high, the citric acid cycle is not able to meet the cell's energy (ATP) demands. When this happens, glycolysis rates shoot way up, to try to compensate for the lack of ATP from the mitochondria. The increased rates of glycolysis relative to the rate of pyruvate use in the citric acid cycle results in a buildup of pyruvate molecules; the extra pyruvate is converted to lactate, which is a negatively charged ion. The production of lactate is NOT the direct cause of the "acid" part of "lactic acidosis." Lactate is not acidic.
When ATP is used for energy (ATP hydrolysis), it is converted to ADP plus an inorganic phosphate molecule. ATP hydrolysis results in an overall increase in acidity, which is the same as an increase in H (protons). Normally, the protons produced during ATP hydrolysis are used in the citric acid cycle. However, when the citric acid cycle is "under-productive"--in other words, when the oxygen supply doesn't meet the demand and the cell has to rely on glycolysis for ATP--then the protons start to build up.
So now, because of the increased rate of aerobic processes in the cell, both lactate and H build up. When too much of something builds up inside a cell, chemical potential pushes it out of the cell and into the plasma. From there, the "extra stuff" will enter the bloodstream. In this case, the "extra stuff" is lactate plus H . Since lactate is a negatively charged ion, and natural solutions tend to be electrically neutral, every lactate molecule that leaves the cell is followed by an H . As the H build up in the blood stream, the acidity of the blood may increase, stay the same, or decrease, depending on the body's ability to buffer the acid. Lactic acidosis is diagnosed by measuring the amount of lactate in the blood.
By the way, though lactic acidosis is characterized by high levels of lactate, neither lactate nor the increase of H (lowered pH) is what damages the body's tissues. Rather, it is the insufficient supply of ATP and oxygen that causes the symptoms of lactic acidosis.
See Related Eating & Diet Communities
Women's Health Newsletter
Find out what women really need.
Featuring Experts
Helpful Tips
Helpful Resources
Expert Blog
Conquering Diabetes - Michael Dansinger, MD
Dr. Michael Dansinger provides thoughtful tips for those with type 2 diabetes or pre-diabetes who want to reclaim their health...Read More
Related News
Related Drug Reviews
- Drug Name User Reviews
Report Problems to the
Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Other Diabetes Information
- Diabetes Health Center
- Dieting Club: 50 – 100 Lbs Member Community Get Support from Members Like You!
- Blog : Conquering Diabetes with Michael Dansinger, MD
-
More Related Communities
The opinions expressed in WebMD User-generated content areas like communities, reviews, ratings, or blogs are solely those of the User, who may or may not have medical or scientific training. These opinions do not represent the opinions of WebMD. User-generated content areas are not reviewed by a WebMD physician or any member of the WebMD editorial staff for accuracy, balance, objectivity, or any other reason except for compliance with our Terms and Conditions. Some of these opinions may contain information about treatments or uses of drug products that have not been approved by the U.S. Food and Drug Administration. WebMD does not endorse any specific product, service, or treatment.
Do not consider WebMD User-generated content as medical advice. Never delay or disregard seeking professional medical advice from your doctor or other qualified healthcare provider because of something you have read on WebMD. You should always speak with your doctor before you start, stop, or change any prescribed part of your care plan or treatment. WebMD understands that reading individual, real-life experiences can be a helpful resource, but it is never a substitute for professional medical advice, diagnosis, or treatment from a qualified health care provider. If you think you may have a medical emergency, call your doctor or dial 911 immediately.
Health Solutions From Our Sponsors
©2005-2013 WebMD, LLC. All rights reserved.
WebMD does not provide medical advice, diagnosis or treatment. See additional information.


