Find Information About:

Drugs & Supplements

Get information and reviews on prescription drugs, over-the-counter medications, vitamins, and supplements. Search by name or medical condition.

Pill Identifier

Pill Identifier

Having trouble identifying your pills?

Enter the shape, color, or imprint of your prescription or OTC drug. Our pill identification tool will display pictures that you can compare to your pill.

Get Started

My Medicine

Save your medicine, check interactions, sign up for FDA alerts, create family profiles and more.

Get Started

WebMD Health Experts and Community

Talk to health experts and other people like you in WebMD's Communities. It's a safe forum where you can create or participate in support groups and discussions about health topics that interest you.

  • Second Opinion

    Second Opinion

    Read expert perspectives on popular health topics.

  • Community


    Connect with people like you, and get expert guidance on living a healthy life.

Got a health question? Get answers provided by leading organizations, doctors, and experts.

Get Answers

Sign up to receive WebMD's award-winning content delivered to your inbox.

Sign Up


All communities will be placed in read-only mode (you will be able to see and search for posts but not start or reply to discussions) as we conduct maintenance. We will make another announcement when posting is re-opened. Thank you for your continued support and patience, and if you have any further questions, please email

Yours in health,
WebMD Community Management

Metformin side effects
ginapocan posted:
When I was diagnosed with Diabetes type 2 some 8 years ago (lost count), the first plan of action combo was Metformin, glipizide, and Actos. I'm currently off Actos due to the side effects. So now its just Metformin and Glipizide, but I take Cinnamon with them. Anyway, when I first got on these meds, there wasn't a whole lot of info out there on them. But, in the past year or so, I have been seeing good info on them. About a year ago, I found the info I needed on Metformin. Well, I read some things that disturbed me. I read somewhere that Metformin can (rarely) cause muscle deterioration. When I read that, nothing clicked right away. But, over time, I began to wonder why my muscles have been shrinking. I used to have an athletic body mass. I passed it off as age related. But, one day it just kept haunting me. So, I sat and reflected as to how long I have been on these meds vs how long it's been since I have had muscle discomfort and muscle deterioration. Between the recent information I received, and the time frame, it added up and believe it's caused by Metformin. It's accelerated over the past year or so. I'm in constant pain. I told my doctor over a year ago, her answer was to put me on insulin. Not try anything else. But continued to prescribe me Metformin. That tells me she didn't believe me. I left her and found other doctors. They won't listen either. One doctor told me it was very rare. So, I guess because it's rare it's not worth investigating. I think this drug is causing a host of issues for me but no one is listening. I don't know what to do. They won't even look at alternatives. What can I do?
An_255018 responded:
Muscles usually "shrink" if they are not used. Are you exercising on a regular basis?

Have you talked to your doctors about other conditions such as arthritis, fibromayalgia or some type of neuropathy that could be causing your pain?

I suppose the only way to really tell if the Metformin is causing these symptoms would be to discontinue the drug for a few weeks and see what happens. You would need to monitor your blood glucose readings carefully and be strict with a low-carb diet and exercise plan. This would be an experiment that you could try but understand the risks and consequences.
brunosbud responded:
Are you exercising, daily? You post a question on muscle loss without a word about muscle growth.

Helpful Tips

A Diabetes Reversal StoryExpert
Many people understand that they can probably improve their diabetes by eating right and exercising, but figuring out how to make it ... More
Was this Helpful?
81 of 153 found this helpful

Expert Blog

Conquering Diabetes - Michael Dansinger, MD

Dr. Michael Dansinger provides thoughtful tips for those with type 2 diabetes or pre-diabetes who want to reclaim their health...Read More

Related Drug Reviews

  • Drug Name User Reviews

Report Problems With Your Medications to the FDA

FDAYou are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.