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    jc3737 posted:
    J Clin Endocrinol Metab. 2011 Oct;96(10):3170-4. doi: 10.1210/jc.2011-1518. Epub 2011 Aug 3. Type of dietary fat is associated with the 25-hydroxyvitamin D3 increment in response to vitamin D supplementation. Niramitmahapanya S , Harris SS , Dawson-Hughes B . SourceBone Metabolism Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111, USA.
    CONTEXT: Mono- and polyunsaturated fats may have opposing effects on vitamin D absorption.
    OBJECTIVE: The purpose of this study was to determine whether intakes of different dietary fats are associated with the increase in serum 25-hydroxyvitamin D (25OHD) after supplementation with vitamin D(3).
    DESIGN, SETTING, AND PARTICIPANTS: This analysis was conducted in the active treatment arm of a randomized, double-blind, placebo-controlled trial of vitamin D and calcium supplementation to prevent bone loss and fracture. Subjects included 152 healthy men and women age 65 and older who were assigned to 700 IU/d vitamin D(3) and 500 mg/d calcium. Intakes of monounsaturated fatty acids (MUFA), polyunsaturated fatty acids (PUFA), and saturated fatty acids (SFA) were estimated by food frequency questionnaire.
    MAIN OUTCOME MEASURE: The change in plasma 25OHD during 2 yr vitamin D and calcium supplementation was assessed.
    RESULTS: The change in plasma 25OHD (nanograms per milliliter) during vitamin D supplementation was positively associated with MUFA, (ß = 0.94; P = 0.016), negatively associated with PUFA, (ß = -0.93; P = 0.038), and positively associated with the MUFA/PUFA ratio (ß = 6.46; P = 0.014).
    CONCLUSION: The fat composition of the diet may influence the 25OHD response to supplemental vitamin D(3). Diets rich in MUFA may improve and those rich in PUFA may reduce the effectiveness of vitamin D(3) supplements in healthy older adults. More studies are needed to confirm these findings.
    Comment in PMID: 21816779 [PubMed - indexed for MEDLINE> PMCID: PMC3200243 Free PMC Article
    jc3737 responded:
    Aging Cell. 2013 Mar 2. doi: 10.1111/acel.12064. [Epub ahead of print> Lipidomics of Familial Longevity. Gonzalez-Covarrubias V , Beekman M , Uh HW , Dane A , Troost J , Paliukhovich I , van der Kloet FM , Houwing-Duistermaat J , Vreeken RJ , Hankemeier T , Eline Slagboom P . SourceNetherlands Metabolomics Centre, The Netherlands; Analytical Biosciences, Leiden University, Leiden, The Netherlands.
    Middle aged offspring of nonagenarians, as compared to their spouses (controls) show a favorable lipid metabolism marked by larger LDL particle size in men and lower total triglyceride levels in women. To investigate which specific lipids associate with familial longevity, we explore the plasma lipidome by measuring 128 lipid species using liquid chromatography coupled to mass spectrometry in 1526 offspring of nonagenarians (59 years ? 6.6) and 675 (59 years ? 7.4) controls from the Leiden Longevity Study. In men, no significant differences were observed between offspring and controls. In women however, nineteen lipid species associated with familial longevity. Female offspring showed higher levels of ether phosphocholine (PC) and sphingomyelin (SM) species (3.5-8.7%) and lower levels of phosphoethanolamine PE (38:6) and long-chain triglycerides (TG) (9.4-12.4%). The association with familial longevity of two ether PC and four SM species was independent of total triglyceride levels. In addition, the longevity-associated lipid profile was characterized by a higher ratio of monounsaturated (MUFA) over polyunsaturated (PUFA) lipid species suggesting that female offspring have a plasma lipidome less prone to oxidative stress. Ether PC and SM species were identified as novel longevity markers in females, independent of total triglycerides levels. Several longevity-associated lipids correlated with a lower risk of hypertension and diabetes in the Leiden Longevity Study cohort. This sex-specific lipid signature marks familial longevity and may suggest a plasma lipidome with a better antioxidant capacity, lower lipid peroxidation and inflammatory precursors, and an efficient beta-oxidation function. ? 2013 The Authors Aging Cell ? 2013 Blackwell Publishing Ltd/Anatomical Society of Great Britain and Ireland.
    ? 2013 The Authors Aging Cell ? 2013 Blackwell Publishing Ltd/Anatomical Society of Great Britain and Ireland.
    PMID: 23451766 [PubMed - as supplied by publisher

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