[a id=aff-1 name=aff-1> From CSIRO Health Sciences and Nutrition, Adelaide BC, South Australia.
Correspondence to Dr Peter Clifton, CSIRO HSN, Gate 13 Kintore Ave, (PO Box 10041 BC), Adelaide SA 5000, Australia. E-mail email@example.com
Next Section AbstractObjective— It is unknown whether a low-fat diet, which may elevate triglycerides and lower high-density lipoprotein (HDL) cholesterol, harms the endothelium. Our aim was to determine whether a low-fat, high-carbohydrate (CARB) diet impaired endothelial vasodilation compared with high saturated fat (SFA), monounsaturated fat (MUFA), or polyunsaturated fat (PUFA) diets. Methods and Results— Forty healthy subjects were randomly crossed over to 4, 3-week isocaloric diets high in PUFA, MUFA, or SFA, containing at least 25 g of the relevant fat or a low-fat, CARB, high—glycemic load diet. Flow-mediated dilatation (FMD), fasting blood lipids, high sensitivity C-reactive protein, plasma intercellular, and vascular adhesion molecules plasma E- and P-selectin were measured after each intervention. SFA impaired FMD compared with all other diets (5.41±2.45% versus 10.80±3.69%; P=0.01). FMD did not change on CARB relative to MUFA or PUFA, despite 23% to 39% rises in triglyceride and 10% to 15% falls in HDL cholesterol. P-selectin was highest after SFA (121±52.7 ng/mL) versus MUFA (98±44.5 ng/mL; P=0.001) and PUFA (96±36.4 ng/mL; P=0.001). Conclusion— High SFA caused deterioration in FMD compared with high PUFA, MUFA, or CARB diets. Inflammatory responses may also be increased on this diet.
This paper is irrelevant because both diets under study were high carb diets and the amount of fat added was only 25g. They just studied the effect of adding fat to a high carbohydrate high insulinemic diets. Adding fat if you already consume high amount of carbs is bad for you. Duh!
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