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    sherm80 posted:
    I guess this is the right "community" to ask this since ibuprofen's side effects involve stomach issues, so, generally, should there be any stomach problems with taking one 400mg ibuprofen at bedtime, on a daily basis?? I hear alot lately regarding negative aspects of the drug, along with Tylenol, so . . .
    srkRN responded:
    It isn't good to take Ibuprofen on an empty stomach due to it's damaging effects on the stomach lining (increased risk of peptic ulcer disease). You mention Tylenol above. It doesn't cause this harm to the stomach. Usually with Tylenol, you would watch the high doses on a regular basis because of possible damaging effects on the liver. This would be especially true if you already had liver problems, or were taking medications known to increase risk for liver damage, or used alcoholic beverages in excess.
    sherm80 replied to srkRN's response:
    I am aware of the eating with Ibu, and even with that, does taking the one 400mg pose any real threat, as long as you coat the stomach?? Frankly, Tylenol works better, but I don't want to have to worry about liver problems (I have no liver issues), cuz I do like my glass of wine with dinner, so there's always something with these drugs. Any thoughts on heart issues and/or strokes with Ibuprofen's use??
    srkRN replied to sherm80's response:
    This may be of help to you and below I have included a couple of helpful links:
    Ibuprofen Tablets, USP[a name="section-1" id="section-1"> [a name="LINK_7dc51257-a888-4885-8436-f15bc3f66fb6" id="LINK_7dc51257-a888-4885-8436-f15bc3f66fb6"> [a name="section-2" id="section-2"> Rx Only
    [a name="LINK_f5c942a1-7153-493e-ba9f-15e0cf62d1ad" id="LINK_f5c942a1-7153-493e-ba9f-15e0cf62d1ad"> [a name="section-3" id="section-3"> Cardiovascular Risk
    • "022 NSAIDs may cause an increased risk of serious cardiovascular thrombotic events, myocardial infarction , and stroke, which can be fatal. This risk may increase with duration of use. Patients with cardiovascular disease or risk factors for cardiovascular disease may be at greater risk (See WARNINGS ).
    • "022 Ibuprofen tablets are contraindicated for treatment of peri-operative pain in the setting of coronary artery bypass graft (CABG) surgery (see WARNINGS ).
    Gastrointestinal Risk
    • "022 NSAIDs cause an increased risk of serious gastrointestinal adverse events including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal. These events can occur at any time during use and without warning symptoms. Elderly patients are at greater risk for serious gastrointestinal events. (See WARNINGS ).

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