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Link between Fragile X gene and fibromyalgia?
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Screennamesrdumb posted:
Researchers in Barcelona screened 353 women with fibromyalgia for the FMR1 gene associated with Fragile X syndrome, a congenital disorder. Four carriers were found in the women with fibromyalgia; none were found in the 125 matched controls. They hypothesize that "the FMR1 premutation may be a genetic factor predisposing females to develop fibromyalgia…" The rate of carriers in the women with FM was double the rate of the general population. More research is needed, but the authors suggest that screening would help to predict the possibility of developing fragile X-associated tremor-ataxia
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Screennamesrdumb responded:
"...In light of this, the molecular test for FMR1 expansion should be recommended in patients with FM as well as
in patients with other described symptoms (anxiety, depression, primary ovarian insufficiency, muscle pain, autoimmune disease, family history of mental retardation or
intellectual disability, among others)."


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