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When I woke up on Tuesday both calves were the same size. Later that evening I was getting dressed to play volleyball and again noticed that my left calf was swollen and much larger than my right calf. After playing volleyball for about 2 hours, the swelling had gone down quite a bit, but the leg was still swollen.
I woke up this morning, Wednesday, and both legs were the same size. Now I'm sitting at my desk at work and I have noticed that my left leg has swollen to be much larger than my right leg.
The swelling is the only symptom I have associated with my calf. There is no pain, no numbness, no bruising. There has been no recent trauma to my leg and I haven't recently changed any exercise or eating habits. The swelling occurs only in my calf and shin (not in my thigh, knee, ankle, or foot).
I'm wondering if anyone has experienced something like this before, if anyone might know why this is happening (if you need more details, I'll be happy to give them if I have them) and/or how seriously I should consider having a doctor look at it. I hate when I go to the doctor and come out feeling like I've wasted his time and my money (I can't count how many times I've heard: "It's just a virus. Drink plenty of fluids and get some rest.").
Thanks, naisse
It would be a good idea to seek medical care for this to ensure your good health. In the meantime, click here for some possibilities, and try our Symptom Checker as well.

Wondering if you had any conclusion to your swollen left calf. I recently began running - about six weeks ago - and was able to run/walk 5 miles this past Sunday. I haven't been too sore at all, however yesterday after sitting at my desk all day I work noticed my left calf began to swell up. It was very numb as well but no pain. I took some IBUprofin and put my leg up last night and the swelling went down tremendously. Today I still have no pain, a little sore/tightness on the back of my calf and thigh but thats it. I know that it is probably just a muscle strain, however I have been reading a lot about blood clots and such. I'd really like to avoid going to the doctor so just wanted to see if you had any word from your doctor or other individuals.
Thanks in advance.
emishy
Thanks,
Possible causes of leg swelling include DVT, lymphedema, and compression of the left iliac vein (May-Thurner syndrome). I haven't found out what is causing the swelling in my case but am going for an MRI to rule out iliac vein compression.
I first noticed my gigantic left calf about 2 weeks ago. I am a long-term jogger and had just started running again after about 4 months off, but never noticed any problem during my runs. Just sitting at the desk. Climbing the stairs sometimes I feel like my legs are made of lead. I am a 46 y.o woman, pre-menopausal, normal weight. 18 months ago I was in the best shape of my life---running, lifting, yoga, tennis, 21% body fat. so I'm spoiled and I'm not prepared to have some freaky immune/cancer/neuromuscular condition!
Things I've ruled out: DVT (venous doppler was negative) cardiac problems (no "pitting", no shortness of breath) Kidney problems (no pitting, BUN & Creatinine normal) Tumor in my Colon (colonoscopy negative) Tumor in my uterus/ovaries (pelvic exam okay) Pretty sure it's not Lymphoma or other retroperitoneal lymphadenopathy (no constitutional symptoms and the swelling isn't consistent with typical lymphedema)
My doctor is stumped, but he is cooperative. Any ideas for further diagnostic workup?
As for the "procedure connection" mentioned by foodie77---no procedures or injury....but I do have a plantar wart on the sole of my left foot! Also some pretty bothersome lower back pain---it's really slowed me down in the past year, which is why I'm out of shape with this stupid mystery illness.
I hope previous posters will come back to this thread and update us!
There are a variety of things that can cause leg swelling, but the surgeon I went to mentioned one in particular that preferentially causes swelling of the left leg: May-Thurner syndrome (AKA iliac vein compression). In this condition, the left iliac vein is compressed, usually between the right iliac artery and a vertebra, leading to fibrosis within the vein, reduced blood flow, and swelling in the leg.
May-Thurner is most often seen in women in their 20s-40s and almost always affects the left leg. Usually an MRI of the pelvis with contrast is needed to see the vein compression, as it often does not show up on ultrasound. The condition increases the risk of developing blood clots in the affected leg, making diagnosis especially important so preventative measures can be taken. Treatments include use of compression stockings, and in some cases procedures such as vein stenting.
Most vascular surgeons know about May-Thurner, but many primary care docs might not be familiar with the condition (as well as other less common causes of leg swelling). So if your PCP is stumped, consider seeing a specialist. In addition, if ultrasound results have been negative, it might be a good idea to have an MRI of the leg/pelvis.
I will update with MRI results once they are in. Good luck to all.
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