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Cancer Treat Rev. 2001 Feb;27(1):9-18. Links Paget's disease of the breast.Sakorafas GH, Blanchard K, Sarr MG, Farley DR. Department of Surgery, 251 Hellenic Air Force General Hospital, GR--115 25 Athens, Greece. georgesakorafas@yahoo.com
Paget's disease of the breast is a rare disorder of the nipple-areola complex that is often associated with an underlying in situ or invasive carcinoma. A change in sensation of the nipple-areola, such as itching and burning, is a common presenting symptom. Objectively, eczematoid changes of the nipple-areola complex are common. The later stages of Paget's disease of the breast are characterized by ulceration and destruction of the nipple-areola complex. Eczematoid changes of the nipple-areola complex and persisting soreness or itching, without obvious reason, is a suspicious symptom for Paget's disease of the breast and calls for thorough evaluation, including mammography. Exfoliative cytology with demonstration of Paget's cells may be useful, but a negative finding does not exclude Paget's disease of the breast. Surgical biopsy is the diagnostic standard and therefore the diagnosis should always be confirmed by open (surgical) biopsy. The histogenesis of Paget's disease of the breast continues to be debated. The epidermotropic theory holds that Paget's cells are ductal carcinoma cells that have migrated from the underlying breast parenchyma to the nipple epidermis. According to the in situ transformation theory, the Paget's cells arise as malignant cells in the nipple epidermis independent from any other pathologic process within the breast parenchyma. This theory has been proposed to explain those cases in which there is no underlying mammary carcinoma or when there is a carcinoma remote from the nipple-areola complex. Each of these theories is plausible; however, treatment approaches differ markedly depending on the theory of histogenesis. Mastectomy has been considered the standard of care in the management of patients with Paget's disease of the breast. Nowadays, however, some patients with Paget's disease of the breast are candidates for breast-conserving therapy. Patients must be selected carefully on an individual basis. Until there is a better understanding of the relationship of Paget's disease of the breast to the underlying cancer the surgeon should understand the natural history and behaviour of this lesion and be aware of both the risks of under- and over-treating patients with Paget's disease of the breast. Copyright 2001 Harcourt Publishers Ltd.
Many dermatology conditions can impact the nipple such as atopic dermatitis, allergic reaction to laundry products, psoriasis, or even Fox Fordyce syndrome (apocrine sweat glands become clogged). Rubbing of the nipple (eg jog bra syndrome) can start nerves firing inappropriately so that the sensation of irritation persists after the area has healed.
I would urge you to see your GYN for a focused breast exam. If indicated you could be referred to a breast specialist/breast surgeon--or a dermatologist.
Yours, Jane

Went back today, doc couldn't find any lumps, but I'm going for a mammogram. I'm 46 this week, and understand there can be false positives with a mammogram at my age.
What worries me, is when I read about pagets, and it says a clear mammography isn't necessarily the all clear for cancer.
So now I'm wondering, if the mammogram comes back clear, should I still be worried or not?
I have not changed soaps, detergents or anything to think it could be allergies. But with the winter here I do feel all my skin dry and occationally itchy could there be that is why my nipples are itchy too? I have never had this before though and every winter I get the winter dry skin.

...I am very scared to find out its cancer but the way I look at things is the quicker they find it the quicker they can fix it and my chances are much greater...I am very scared though.. 
Thanks for your help.
Thanks for your help.
Any advice?
I've found it somehow comforting to know that i'm not the only one who has these symptoms and that actually it seems fairly common.
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