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Post-Op Open Heart Double Bypass Surgery with blood clotting (occlusions)
Jerrykloeb posted:
Greetings All!

Synopsis: 50 year old female, recent non-smoker, consistent history of low blood pressure and two double bypass heart surgery prodedures.. Post-op events after several weeks; blood clotting within the grafted arteies/veins. No problems with the grafts per se. Pre-op(s) blood clotting proven to almost completely impede proper blood flow to the Lower Artery Descending (LAD) with seven stents previously pre-op(s) implaced. Consistent low blood pressure compounded with moderate to extreme post-op angina attacks. Our family is asserting to the Cardio Team that a full panel blood CBC Differential screen et al; be done in order to determine what is causing the consistent problem of blood clotting and inducing MI episodes. Plavix and asprin have not been effective to date.

Any positive comments and/or suggestions as to what-next investigations need to be done; shall be greatly appreciated.

Best regards,

Jerry K. Loeb
(760) 772-8396
Palm Desert, CA
cardiostarusa1 responded:
Hi Jerry:

"Our family is asserting to the Cardio Team that a full panel blood CBC differential screen et al; be done......"


Also, consulting with a hematologist sounds warranted.

As reported, as applicable, it's known that some individuals are more prone/prone to developing (at any time) arterial blood clots due to specific factors and conditions, such as an extra copy of a chromosome (causing hypercoagulation), etc.

"Plavix and aspirin have not been effective to date."

Very noteworthy, as applicable, some individuals can be resistant (a non-responder) to antiplatelet drugs such as common aspirin and/or Plavix.

Take care,


WebMD community member (since 8/99)



Be well-informed

As Applicable

Aspirin-resistance? / Plavix-resistance?

VerifyNow helps identify patients who are resistant to aspirin's benefits. The test is a quick, easy blood test that can be performed right in the doctor's office. One simple number indicates if a person is an aspirin responder and adequately protected, or if they are resistant and missing out on aspirin's protective effects.

"Aspirin resistance is a very serious concern among patients with chronic cardiovascular disease but most patients are unaware of the problem. There are millions of people who diligently take their aspirin every morning believing that they're helping to protect themselves when, in fact, they're getting little, if any, benefit."

- Daniel I. Simon, MD, associate director interventional cardiology, Brigham and Women's Hospital, Boston MA.


Covering all the bases

The VerifyNow System is the first, simple and accurate system for measuring the individual response to multiple antiplatelet agents. Addressing EVERY MAJOR antiplatelet drug, including aspirin, Plavix, ReoPro, and Integrilin.


The AspirinWorks test is performed by a clinical laboratory on a random urine specimen. Increased levels of 11-dehydrothromboxane B2 in the urine are an indication that your dosage of aspirin is not effective for decreasing the risk of a heart attack or stroke. However, decreased levels of 11-dehydro thromboxane B2 indicate that your aspirin dose is working.

WebMD article - archives

May 5, 2008

'Aspirin Resistance' May Be Common

New Review Long on Questions, Short on Answers About Aspirin Resistance and Heart Health


Good to know, for the primary and secondary prevention of heart attack and brain attack/stroke

Epidemiologic studies (EDS) have revealed risk factors for atherosclerosis (typically affecting the coronary, carotid, and peripheral arteries), which includes age, gender, genetics (gene deletion, malfunction or mutation), diabetes (considered as being the highest risk factor), smoking (includes secondhand), inactivity, obesity (a global epidemic, "globesity"), high blood pressure (hypertension), diet high in fat, saturated fat and cholesterol, high LDL, high Lp(a), high ApoB, high Lp-PLA2, high triglycerides, low HDL (less than 40 mg/dL, an HDL level of 60/65 mg/dL or more is considered protective against coronary artery disease), high homocysteine, and high C-reactive protein (CRP/hs-CRP).



"Be a questioning patient. Talk to your doctor and ask questions. Studies show that patients who ask the most questions, and are most assertive, get the best results. Be vigilant and speak up!"

- Charles Inlander, People's Medical Society


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