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    Omeprazole and Irregular Heart Beat
    Parttimer posted:
    I am a 44 yo male who started having an irregular heart beat during exertion last week. I noticed a "strange feeling" in my chest during brisk walking and then after a few episodes checked my pulse and noticed it skipping once every 5-6 beats. This accompanied the strange feeling each time. Completelty normal after a few minutes of rest. After a visit to the ER and the usual test (EKG, Blood, X Ray) to rule are heart attack, and consuly with Cardiologist, I was sent home. Even though I told them it was only during exertion, they took me for a slow stroll around the ER (an 18mo could have gone faster) - well of course that didn't show anything because there was no exertion. Follow up with Cardiologist later today.
    Of course it continued over the weekend. I did notice that with the starnge feeling / skipped beat, I get a slight pain in my stomach. I also noticed a lot of gas/belching. Nothing I gave any thought to earlier as I have had acid reflux for 15 years now and gas/belching is common at times. I have been on Omeprazole for probably 5 years now and read some of the side effect and an irregular heart beat is one of them.
    Has onyone heard of this?
    cardiostarusa1 responded:

    "Has anyone heard of this?"

    Check out -


    Omeprazole side effects

    Ask A Patient

    Rate a drug, side effects, comments, etc.

    "Started having an irregular heartbeat during exertion"

    "Checked my pulse and noticed it skipping once every 5-6 beats."

    "Have been on omeprazole for probably 5 years now and read some of the side effect and an irregular heartbeat is one of them."

    As applicable, and typically not related to taking any particular drug, some individuals may notice that they are suddenly having palpitations only when doing things such as vigorous exercise (i.e., exercise-induced arrhythmia, EIA).

    The most common type of palpitations, premature ventricular contractions (PVCs, occurs even in many heart-healthy individuals), described that the heart is flip-flopping, fluttering, jumping, pausing or stopping briefly (though it's actually not doing that), pounding, SKIPPING, thumping, or strong, hard, or forceful beats being felt in the chest, neck, throat, has various causes or triggers.

    PVCs are typically harmless/benign, be it isolated (single), couplets (2-in-row), triplets (3-in-a-row) or salvos (short bursts of 3 or more in-a-row), bigeminy (occurring every other beat), trigeminy (occurring every third beat), quadrigeminy (occurring every fourth beat), etc.

    However, the main problem or concern (even more so, much more emphasized for those with certain major or serious heart conditions) with PVCs is when sustained ventricular tachycardia (runs of PVCs over 30 seconds) occurs.

    Also, non-sustained ventricular tachycardia (runs of PVCs under 30 seconds, but typically not salvos) may/can become serious as well if it occurs frequently (episodes are grouped closely/tightly together).

    Additionally, of the different types of heart conditions, various symptoms can be acute (occurring suddenly), be chronic (occurring over a long period of time), come and go (be transient, fleeting or episodic (such as an irregular heartbeat, requiring the use of a Holter monitor or event recorder at home and during daily activities), or even be silent.

    be proactive in your health care and treatment. Best of luck down the road of life.

    Take care,


    WebMD community member (since 8/99)



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    Jeshuler08 responded:
    Hello I have similar problem.
    I stop teking the protonix my PVC is less but my acid reflux is worse.
    Only I am taking Zantac and diet.

    If you have any solution please contact me
    dada1111 responded:
    Yes and have you noticed any Tacky Cardia (very fast heartbeat) I have tried to stop the Omeprazole and the reflux comes back. Does anyone know of anything else besides Omeorazole to control the reflux? Thanks
    cardiostarusa1 replied to dada1111's response:

    General info


    Prilosec Alternatives

    Take care,




    WebMD/WebMD forums does not provide medical advice, diagnosis or treatment.

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    undefined responded:
    Wow, I noticed the very same heart symptoms after about one month of switching from Omeprazole to Protonix (40). And just before I was switched, I'd had a complete cardiac workup, all came out perfect. I'm very active, and didn't notice the pounding and skipping until recently. Now I'm afraid to do anything strenuous, as the skipping causes me a lot of anxiety, which makes my heart pound even faster. I stopped taking the Protonix 2 days ago, so I'll have to wait and see. There has to be something better than long term PPIs ... this is a nightmare. I wish you luck; hope my info helped.

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