Hi:
Wondering if it was safe to...."Matters of safety can not be properly addressed via the Internet.
"Worry that the propranolol may reduce my bp too much." Since beta-blockers are designed to lower the heart/pulse (H/P) rate and blood pressure (BP), it is essential to closely monitor this.
Normal resting range H/P rate is 60-100 beats per minute (BPM). Average resting H/P rate in men is 72-78 BPM and in women is 78-84 BPM. Under 60 BPM is bradycardia (slow heartbeat).
Normal resting BP is under 120/80, with 110/70 or 115/75 reported as being optimal/ideal. Under 90/60 is defined as low BP (hypotension).
If/when H/P rate and/or BP becomes too low, symptoms may/can occur, which includes lightheadeness or dizziness, confusion, weakness, or even syncope (temporary loss of consciousness (includes fainting, passing out).
About beta-blockers This class of drug is notorious for causing problems (mainly due to side effects, which includes fatigue, tiredness, lack of energy, weakness, lethargy), though this can not be predicted or pre-determined.
There are two
broad categories of beta-blockers, lipophilic and hydrophilic. Studies in the past have showed that lipophilic beta-blockers,
includes propranolol, are more likely to cause central nervous system-related side effects (e.g., bad dreams, nightmares or hallucinations), than hydrophilic beta-blockers.
Beta-blockers are also considered selective or nonselective, that is, the selective type technically only affects beta 1 receptors and non-selective type can affect both beta 1 and beta 2 receptors.
Selective = typically (though not always), a decrease in systemic side effects, non-selective = typically (though not always), an increase in systemic side effects.
Eveyone is biochemically and metabolically different. An individual's metabolism responds differently to beta-blockers. Also, a problem with this drug is that some beta-blockers are known to cross the blood brain barrier easier than others.
Though ominous sounding, this barrier is actually a body-friendly network of blood vessels and cells that filters blood flowing to the brain.
For example,
it is reported that propranolol (non-selective) crosses the barrier rather easy and this is apparently why it causes more central nervous system side effects such as nightmares, hallucinations and depression, than the beta-blockers that do not cross into the barrier (low penetration characteristics) as easy.
Non-selective beta-blockers may/can increase lipids and worsen blood sugar tolerance. They might also exacerbate respiratory abnormalities in those with reactive airway disease.
About side effects It is said that medicine is a science of uncertainty and an act of probability. For many, prescription drug-therapy, is a
hit or miss, trail and error affair.
Side effects may/can diminish or disappear as the body adjusts itself to the drug, though sometimes, one will simply not be able to tolerate a certain drug (or drugs) at all, at any dose.
Factors and conditions such as age height, weight, gender, genetics and metabolism may/can come into play in determining who experiences side effects and who does not.
Pharmacogenomics is the study of the interplay between genes and drugs which helps to explain why prescription drugs have different effects in different individuals. Genetic variation in one or more genes may be the basis for a therapeutic failure or for an adverse drug reaction.
Without lowering the dosage (unless that is applicable), sometimes, taking a particular prescription drug at a different time of the day or taking it with food may/can improve the side effect-related situation.
Sometimes, changing to another same-class drug or taking a lower dose of the drug along with another class of drug (for a combo-action) may/can impove the side effect-related situation.
Take good care,
C*