Skip to content
My WebMD Sign In, Sign Up
C677T MTHFR
avatar
love2volunteer posted:
Recently diagnosed with C677T MTHFR and can not find a lot of information on it. I know it can lead to premature cardiovascular disease (which I already have a STRONG history of) Would love more information on it.
Reply
 
avatar
CardiostarUSA1 responded:
Hi:

"Can not find a lot of information on it"

Actually, there is a good amount of info on it out there.

Here's a randomly selected article -

(Circulation. 2005;111:e289-e293.) 2005 American Heart Association, Inc.

Cardiology Patient Page

Homocysteine and MTHFR Mutations

Relation to Thrombosis and Coronary Artery Disease

www.circ.ahajournals.org/cgi/content/full/111/19/e289

"Cardiovascular disease (which I already have a STRONG history of)"

Most important, communicate/interact well with your doctors to keep ALL known modifiable risk factors for cardiovascular disease (which actually begins very early in life, even as early as in the pre-teen/teenage years) closely in-check. Best of luck down the road of life.

Take care

CardioStar☆

WebMD community member (8/99)

-

-

☑Be well-informed

MTHFR (methylenetetrahydrofolate reductase)

MTHFR is a gene in the human body that produces an enzyme, which helps in the processing of amino acids. If one has a mutation of this gene, certain medical problems may/can arise.

If/when there is a MTHFR gene mutation (of gene C677T), it can cause an elevated level of homocystine (Hcy), called Hyperhomocystenemia. Elevated levels of homocystine have been linked to cardiovascular disease (atherosclerosis), which can lead to a heart attack, and/or brain attack.

-

Heart-Healthy Foods

It's never too late

Avoid foods high in saturated fat and cholesterol. Choose skim or low-fat milk, low-fat yogurt and reduced-fat cheeses. Eat more fish and poultry. Limit servings to five to seven ounces a day. Trim visible fat. Limit egg yolks. Substitute two egg whites for one whole egg or use an egg-substitute. Eat more fruits and vegetables, whole grains, breads and cereals. Use less salt and fat. Season with herbs and spices rather than with sauces, gravies and butter.

-

MSNBC

The Today Show - Archives

How to eat your way to cardiovascular wellness - 1/26/06

In 'The Road to a Healthy Heart Runs Through the Kitchen', Joseph C. Piscatella offers nutritional analysis and recipes. Read an excerpt.

msnbc.msn.com/id/11044374

Good to know, for the primary and secondary prevention of heart attack and brain attack/stroke

Epidemiologic studies (EDS) have revealed risk factors for atherosclerosis (typically affecting the coronary, carotid, and peripheral arteries), which includes age, gender, genetics (gene deletion, malfunction, or mutation), diabetes (considered as being the highest risk factor), smoking (includes secondhand), inactivity, obesity (a global epidemic, "globesity"), high blood pressure (hypertension), diet high in fat, saturated fat and cholesterol, high LDL, high Lp(a), high ApoB, high Lp-PLA2, high triglycerides, LOW HDL (less than 40 mg/dL, an HDL level of 60/65 mg/dL or more is considered protective against dreaded coronary artery disease), high homocysteine, and high C-reactive protein (CRP/hs-CRP).

- -

Health A to Z

Making the Most of Your Doctor Visits

www.healthatoz.com/healthatoz/Atoz/common/standard/transform.jsp?requestURI=/healthatoz/Atoz/hc/men/life/alert05132004.jsp

HealingWell

You and Your Doctor: It Takes Two to Tango

Your medical care is a TWO WAY street......

www.healingwell.com/library/health/article.asp?author=salvucci&id=5

Quote

"Be a questioning patient. Talk to your doctor and ask questions. Studies show that patients who ask the most questions, and are most assertive, get the best results. Be vigilant and speak up!"

- Charles Inlander, People's Medical Society

.

It's your future......be there.

☛Your Health is your Wealth
 
avatar
love2volunteer responded:
thank you for the helpful information!
 
avatar
CardiostarUSA1 responded:
You're welcome.

Take good care,

C-☆


Featuring Experts

James Beckerman, MD, FACC, is a cardiologist at the Providence St. Vincent Heart Clinic in Portland, OR. He graduated summa cum laude from Harvard Col...More

Helpful Tips

Coffee Can Lower Depression Risk in WomenGuest Expert
http://online.wsj.com/article/SB10001424052970204010604576594853506227020.html More
Was this Helpful?
1 of 1 found this helpful

Expert Blog

The Heart Beat - James Beckerman, MD, FACC

Dr. James Beckerman shares how small, livable lifestyle changes can have a real impact on your risk of heart attack and stroke...Read More

Related Drug Reviews

  • Drug Name User Reviews

Report Problems to the
Food and Drug Administration

FDAYou are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

For more information, visit the Duke Health General and Consultative Heart Care Center