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    601bbref posted:
    Taking both plavix and nexuim taking nexuim in the morning and plavix at bedtime is this a problem? Or is it just when you take the meds together.
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    James Beckerman, MD, FACC responded:
    There are interactions between PPI's like Nexium (and others) and Plavix - the PPI may reduce the benefit of the Plavix. While it is true that some PPI's have less of an interaction than others, I generally would try to avoid taking both of them if possible (even if taken at different times of day), especially if you are on a shorter course of Plavix. Discuss your situation with your doctor, and you may find some alternatives to the PPI.


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