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    Telomeres, Gene Expression etc
    EngineerGuy posted:
    Hi folks,

    Dr. Ornish has continued to make amazing contributions to the health of our nation.

    Dr. Elizabeth Blackburn 2009 Nobel Prize winner in Medicine
    The Nobel Prize in Physiology or Medicine 2009 was awarded jointly to Elizabeth H. Blackburn, Carol W. Greider and Jack W. Szostak "for the discovery of how chromosomes are protected by telomeres and the enzyme telomerase". (1 hour)

    1.Increased telomerase activity and comprehensive lifestyle changes: a pilot study. Ornish D, Lin J, Daubenmier J, Weidner G, Epel E, Kemp C, Magbanua MJ, Marlin R, Yglecias L, Carroll PR, Blackburn EH. Lancet Oncol. 2008 Nov;9(11):1048-57. Epub 2008 Sep 15. Erratum in: Lancet Oncol. 2008 Dec;9(12):1124.
    PMID: 18799354

    Ornish has collaborated with Dr. Elizabeth Blackburn, 2009 Nobe Prize winner in Medicine, for studies showing Ornish program lengthened telemeres and increased enzyme telomerase 29% in 3 months.

    2. Clinical events in prostate cancer lifestyle trial: results from two years of follow-up. Frattaroli J, Weidner G, Dnistrian AM, Kemp C, Daubenmier JJ, Marlin RO, Crutchfield L, Yglecias L, Carroll PR, Ornish D.
    Urology. 2008 Dec;72(6):1319-23. Epub 2008 Jul 7.
    PMID: 18602144

    Followup to Dr. Ornish's prostate cancer trials. Recall that the Ornish group had 70% apoptosis, compared to control group 9% apoptosis, after a year. Both groups had 7% apoptosis at the beginning. Apoptosis is cell suicide, which a good cancer cell should do.

    Original study:

    3. Changes in prostate gene expression in men undergoing an intensive nutrition and lifestyle intervention. Ornish D, Magbanua MJ, Weidner G, Weinberg V, Kemp C, Green C, Mattie MD, Marlin R, Simko J, Shinohara K, Haqq CM, Carroll PR. Proc Natl Acad Sci U S A. 2008 Jun 17;105(24):8369-74. Epub 2008 Jun 16.

    free full text:

    Genes which encourage prostate cancer, were measured to be down-regulated (suppressed), and genes which discourage prostate cancer, were measured to be up-regulated.

    Everyone has a few genes we wish we did not have. This data actually showed that genes are not fate.

    Amazing stuff !!

    Best regards, EngineerGuy
    raboof responded:
    Nice three minute video summarizing Dr. Ornish's Editorial in the American Journal of Cardiology regarding the systemic benefits of a low-fat plant-based diet --
    EngineerGuy replied to raboof's response:
    Hi Raboof,

    Thanks very much for the excellent video link.

    Best regards, EngineerGuy
    josvin84 responded:
    Really interesting talk given by Elizabeth Blackburn.

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