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Alinia for HCV Genotype 4
Melissa Palmer, MD posted:
Alinia has been used successfully in patients with HCV genotype 4 when predosed prior to starting Peginterferon and ribavirin.
Among the 96 treatment-naive patients, the SVR rate was 79% in the triple therapy arm, compared with 61% in the nitazoxanide-pegylated interferon dual therapy arm, and 50% in the standard-of-care arm (P = 0.023).

? Among the 24 treatment-experienced patients, the SVR rate was 25% in the triple therapy arm compared with 8% in the nitazoxanide-pegylated interferon arm.

? RVR, EVR, and ETR rates are shown in the table below (see next study description).

? Adverse events were generally similar across all 3 treatment arms.

? The exception was that the rate of anemia was significantly lower in the group that did not receive ribavirin.
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billm57 responded:
is alinia being studied with any other genotype
Melissa Palmer, MD replied to billm57's response:
Yes, studies are ongoing with genotype 1. But, my anecdotal experience did not show increased efficacy in G1 HCV.
billm57 replied to Melissa Palmer, MD's response:
thank you - i did see the one study had 3 type1 patients - but thats not quite enough to form a conclusion
Alef1 responded:
Has there been any experience with the treatment of genotype 4 with Boceprevir or Telaprevir? Has Alinia been tried with these new drugs?

Thanks for your help
Melissa Palmer, MD replied to Alef1's response:
Telaprevir has antiviral activity against genotype 4 but is considered off label use
Melissa Palmer, MD replied to Alef1's response:
Alinia is no longer being studies

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