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    Alinia for HCV Genotype 4
    avatar
    Melissa Palmer, MD posted:
    Alinia has been used successfully in patients with HCV genotype 4 when predosed prior to starting Peginterferon and ribavirin.
    Among the 96 treatment-naive patients, the SVR rate was 79% in the triple therapy arm, compared with 61% in the nitazoxanide-pegylated interferon dual therapy arm, and 50% in the standard-of-care arm (P = 0.023).

    ? Among the 24 treatment-experienced patients, the SVR rate was 25% in the triple therapy arm compared with 8% in the nitazoxanide-pegylated interferon arm.

    ? RVR, EVR, and ETR rates are shown in the table below (see next study description).

    ? Adverse events were generally similar across all 3 treatment arms.

    ? The exception was that the rate of anemia was significantly lower in the group that did not receive ribavirin.
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    billm57 responded:
    is alinia being studied with any other genotype
     
    avatar
    Melissa Palmer, MD replied to billm57's response:
    Yes, studies are ongoing with genotype 1. But, my anecdotal experience did not show increased efficacy in G1 HCV.
     
    avatar
    billm57 replied to Melissa Palmer, MD's response:
    thank you - i did see the one study had 3 type1 patients - but thats not quite enough to form a conclusion
     
    avatar
    Alef1 responded:
    Has there been any experience with the treatment of genotype 4 with Boceprevir or Telaprevir? Has Alinia been tried with these new drugs?

    Thanks for your help
     
    avatar
    Melissa Palmer, MD replied to Alef1's response:
    Telaprevir has antiviral activity against genotype 4 but is considered off label use
     
    avatar
    Melissa Palmer, MD replied to Alef1's response:
    Alinia is no longer being studies


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