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Positive, but whats wrong with the tests ?
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Anon_228959 posted:
First, thanks very very much for every one here in this site, for your answer, and comments.

The things thats I was exposed by unprotected vaginal sex ( I am male) ,one time to a confirmed HIV+ women, she has a vaginal condidos, so very very unusual heavy and smelly vaginal liquide, so the risk was even higher. 2 weeks later have all the typical symptoms, yes typical, as high fever 40 C, macculopapular rash in torse, diaria with blood and muccus and rectal hemorragia, skin petachia (due to acute low palletes), mouth ulceration in the inside of cheekand petachia, white swollen tongue and yeast infection around my penis, painfull testicule, then after the symptomes went away after around 4 weeks of on set, I am left up to today with neuropathy (confirmed with EGG and EMG, blurred vision, and then a generalised lymphadenopathy, have tender painfull lymph nodes in every place in my body, groin, arm pit, neck, behind ears, elbow, chest, knee, even in face, tested neg up to 3 months, then had sex with my wife, then 2 weeks, she start to have acute HIV like symptomes with the usual symptomes, we ruled out all other causes (heavy work was donne thankfully by medical staf here in Montreal, EBV' CMV' TOXO, rubella, auto immune, rhumato, lupus, cancer..etc all negative ), we both tested neg up to 8 months by 4th generation tests, I tested at 6 months by DNA-PCR, RNA-PCR and one viral load, all negative. but still concerned over a low WBC, neuropathy of both of us, and specially the persistant generalised lymph sweelling till to day 10 months, doc dont know what to think, but logically, by the exposure to HIV + person, typical symptomes, in both me and wife. I am 99.9999 % that its HIV infection, that may or may not show later. so, my docs advice to continue testing, will have 10 months tests tommorow, I Know almost without a doubt that we are infected, because as every single cause was ruled out, after a 8 months of medicales tests, nothing found, but declining umminity, neutrophil and WBC, just at the on set of the symptomes, a doc who tested me at 3 weeks, when he sow the rash, I think was so positive that I was Infeted.so he run a CD4 CD8 stright away , as a base line, as he expected a positive result one or two weeks later, thats did not happen.
now at 8 months my CD4 lowered from 920 to around 340, only in about 6 months. So that why because of all those parameter : exposition unprotected to HIV+ who has Very very heavy vaginal liquide and yeast infection, my typical symptomes (even if people say there is no typical, but the HIV Doc I sow first when the onset of my symptomes. who treated HIV person since 1982, fist time he sow the rash on my bosy said : get test HIV, and had run the test for CD4 CD8 as base line, as he was positive that I was infected !). my wife acute symptomes and neuropathy, and blood work that show acute immune defeciency compatible with the acute infection. I Know that I and sadly my wife are infected, but hope to show in test before i had even lower CD4 and aids. as its logical that no treatment will be offer against HIV- till test show up in test, but I fear That will be late as My CD4 are now in treatment starting range, by guidline here in canada.

Thanks for reading this long post, but that what it need to explain my cases.
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David J Malebranche, MD, MPH responded:
Good morning sir,

I'm sorry to hear about all your are going through with this, At six months, if your symptoms were that severe AND due to HIV, your RNA PCR should have been high or elevated. It also may depend on which type of HIV they are testing for, HIV 1 or 2. Not sure what they test for in Montreal, but I imagine they test for both, but that could be the reason why the tests have been negative to this point. Or, if the tests are negative at 10 months, you may want to go to another medical facility with all your paperwork and get a fresh set of eyes to look at your case.

Please keep us updated and let us know how the tests went!

David
 
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Queb23 replied to David J Malebranche, MD, MPH's response:
Thanks Doctor for your response,
All my test were ABBOT AXYM Elisa 4th generation HIV1/2 ab/ag.
My HIV PCR test was HIV 1 Aptima RNA test.
viral load was Amplicor 1.5
and my DNA PCR was HIV 1 from roche .
My 10 month test was MEDMIRA HIV1/2.

This week, I have a blood work, My wbc jump to normal range from 4.5 during the last 10 months (since exposure) to 7500, my neutrophils too jumped from 2000 during the last 10 months (since exposure) to 4000, as well my lymphocyte counte from 1500 to 2400,
My lymph modes are getting less painfull, and some has gonne away, BUT, tI have for the first time HIGH ALT 70 (norm 40), but normal AST.
My hypothysis is may be the virus were retained in lymph nodes, what explain the different low wbc numbers, and normal ALT, now may be the virus is spreading in blood what cause the lymph node te shrink, and what causes the liver inflamation with high ALT.
I fear that Now I am seroconverting, and my test will turn positive now, What do you think Doctor about this hypothesis, does it make sense ?
If yes, How could I infected my wife if there is no virus in blood up to 10 months.
Is a Variant virus make more sense, and I maight seroconverted a long time and now I am reaching set point, but the virus is so divergent that was undetectable in test.
Thanks very very much Doctor for you input.
 
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David J Malebranche, MD, MPH replied to Queb23's response:
Hello,

It makes sense, your hypothesis, as during acute retroviral syndrome you can have low wbc, high ALT and AST, low platelets, etc. A high ALT but normal AST usually signifes some kind of viral infection, maybe hepatitis B or C, so make sure you get checked out for those too. I wish I could explain it to you, but its difficult as I haven't seen you and reviewed your whole case. I'm not sure whether it may be another infectious disease that could be causing your symptoms. It seems like you have seen an Infectious Disease specialist at this point, but if you haven't, you should see someone else like I said so that a fresh set of eyes can examine your case.

I don't know if I would agree that the virus is hiding in your lymph nodes, and so that's why the viral load is negative, as if you are having symptoms that severe, it is in the blood, and having that many tests come back negative, particularly the viral load test, doesn't make sense - only if its another viral infection causing this, NOT HIV, and that is where your physicians need to look. Anything I would guess would be speculation, and I can't do that at this point.

But keep thinking things through and following up on your labs and tests... I'm sure they will find an answer as to what is going on.

David
 
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ashler replied to Queb23's response:
Did you find the reason to your problems? I hope so.
 
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wantonjoe replied to ashler's response:
Queb23's case was very interesting, and he posted about his problem across almost every HIV forum there is - thebody.com, poz forums, web md etc.

He obviously suffered a very serious illness that lowered his CD4 count, lowered his immunity and left him prone to opportunistic infections. His abnormal bloodwork also showed characteristic signs of HIV, such as low platelets, low WBC's, etc.
Then his wife began to suffer similar problems after an unprotected exposure to him.

Does anyone know what happened to him?
Or Queb23, if you are still reading these forums, please update us ? It will be a great support to many people who may be going through a similar problem.
 
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birdman2900 replied to wantonjoe's response:
I read this guy's story too, on multiple forums. Here is the last update I could find (Destin32 in this thread): http://www.healthboards.com/boards/hiv-prevention/896868-seronegative.html
 
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wantonjoe replied to birdman2900's response:
Thanks for sharing birdman.
Fascinating. Hope the guy has recovered and is back to normal, and same of course for his wife.
He had a great way of sensationalist writing that really conveyed his sense of panic to the reader - he should have been a horror writer!

Queb / Destin - if you are out there, give us a shout - we are thinking of you.
 
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chillq8 replied to wantonjoe's response:
My case is ridiculously similar to his, similar exposure, symptoms, timing and similar CBC findings. For me it just matter of time before i get to the bottom of this, HIV or not.

I may have infected my wife as similar symptoms also happened to her, if not stronger!.

My tests were: 4 weeks combo - NEG 12 weeks combo - NEG 5 months elisa - NEG
 
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j4a2y01 replied to chillq8's response:
Chill,
What have your symptoms been like. This is going on w me as well. 3 days after exposure worst case of chapped lips ever, so bad my lips were bleeding. 2 weeks terrible headaches, night sweats a vibration like feeling in stomach, and psoriasis like rash, and terrible pain in back for two days. Had a very low grade fever. Week 4 everything but the rash stopped. Oraquick home testing at least once a week through it all, negative. About the 7th week started getting slight numbness in feet, week 8 it had turned into full blown numbness and pain. Muscles aching, difficulty with balance, very intense and it includrd my hands. Went to er, they ran cbc everything normal wbc count 5.2, which is low end of normal. Continue testing through it all with oq and all negative. Week 13 another oraquick negative, have been on here so everyone was saying conclusive not HIV. I stay off the net weeks 13-18, tested week 17 to be sure, negative. My hands and feet are getting better but I have a small swollen lymph node in kneck and a sore throat. 2 days ago I tried finding cause of guillain barre which I'm sure is what I have. Main cause is HIV infection and cytomegalovirus, but I'm still negative. I don't understand. I also had high blood pressure and high heart rate. I couldn't tell if at 14 weeks I had a rash or just pimples. I've had cold sores in mouth as well. Now gbs feels like its starting to go away but muscles feel weak. I've also had a little bit of mucus in stool. Seems like I bruise easy as well but can't know for sure as I could be over sensitive. Today I see Shaun's post and it has got me to panic mode again.


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