Skip to content
Impressive Antihypertensive Effect With Flaxseed
avatar
billh99 posted:
Rodriguez explained that the trial, FLAX-PAD, was conducted in PAD patients because they happened to have a clinic for the disease in their center and, as around 75% of PAD patients have concomitant hypertension, "it was an easy population to study."
Subgroup analyses of only the PAD patients with hypertension showed a greater reduction in SBP, of about 15 mm Hg, in these patients than in the study population as a whole and a similar reduction in DBP, he noted.
"Flaxseed represents a particularly attractive strategy for controlling hypertension in economically disadvantaged communities and countries, and its BP-lowering effects compare favorably with those of antihypertensive drugs and lifestyle modifications, such as a low-salt diet and weight loss," he noted.
...
Rodriguez said that he and his colleagues chose to study flaxseed because animal studies have shown it has antiatherogenic, anti-inflammatory, and antiarrhythmic effects and may reduce circulating cholesterol and trans-fatty acid levels.
They randomized 110 patients with PAD and an ankle-brachial index (ABI) <0.9 to milled flaxseed (30 g/day) in the form of bagels, muffins, and buns (n=58) or placebo products (n=52), made from wheat with a similar flavor, for one year.
Baseline characteristics were similar between the two groups, with hypertension being highly prevalent--around three-quarters of the PAD patients had high blood pressure, and 80% were taking antihypertensive medications. BP measurements were based on an average of three readings taken in the sitting position with a mercury sphygmomanometer by a trained nurse.

...
"Flaxseed has different components, including alpha-linolenic acid, enterolignans, and fiber, and all have been shown to decrease BP. We think we are seeing a synergistic effect of different compounds," he commented.



A year long followup is in the works.
Was this Helpful?
2 of 3 found this helpful
Reply


Helpful Tips

WARNING! - Grapefruit and meds (heart and others)
This will probably show up in a day or two, but I felt that it should be posted now. For a long time there has been a warning about the ... More
Was this Helpful?
6 of 6 found this helpful

Related Drug Reviews

  • Drug Name User Reviews

Report Problems With Your Medications to the FDA

FDAYou are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

For more information, visit the Duke Health General and Consultative Heart Care Center