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WARNING! - Grapefruit and meds (heart and others)
billh99 posted:
This will probably show up in a day or two, but I felt that it should be posted now.

For a long time there has been a warning about the consumption of grapefruit juice and a few meds. The package insert for simvastatin warns against a quart or more.

But new study indicates that many more drugs are affected and it can happen with a small glass of juice and probably a 1/2 of whole grapefruit. And the affect can last over 24 hrs.

Also some meds for cancer, inflammation, diabetic, and several other conditions are also affected.

From a blog on here is a list of the heart related meds.

For now, there are enough data to support the recommendation for banning grapefruit and grapefruit juice altogether from the diets of those on certain cardiovascular medications. For laypersons who read my blog, I'll add the names under which these compounds are marketed. (For a more complete list, check They include:

Rhythm agents:

Amiodarone (Pacerone).
Dronedarone (Multaq).
Quinidine (not commonly prescribed).

Cholesterol agents:

Atorvastatin (Lipitor).
Lovastatin (Mevacor).
Simvastatin (Zocor).

The new anticoagulant rivaroxaban (Xarelto), prescribed in placed of warfarin in some.

High-blood-pressure meds:

Nifedipine (Procardia).
Verapamil (Verelan).
Felodipine (Plendil).

Antiplatelet agents:

Ticagrelor (Brilinta).
Clopidogrel (Plavix)—in this case, it completely nullifies the effect of Plavix instead of exaggerating it, as in the other meds listed above.

In addition, there is an interaction with the heart-failure diuretic eplerenone (Inspra).

I note that sirolimus is also listed here, and I'm curious about patients with stents coated with sirolimus (the older Cypher stents), but I don't know of any data or case reports that directly address this issue.

Here is a news story about this.

And here is a list of the meds, the effect, and possible alternates from the Canadian Medical Journal.
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Elizabeth_WebMD_Staff responded:
You were correct Bill, the article showed up. Thanks for this info. Here is the link -

Drugs That Interact With Grapefruit on the Rise

lionbaby73 responded:
I learned about this grapefruit/medicine interaction when I got my depression pills. I thought it was weird but I haven't touched anything grapefruit related since I got them....

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WARNING! - Grapefruit and meds (heart and others)
This will probably show up in a day or two, but I felt that it should be posted now. For a long time there has been a warning about the ... More
Was this Helpful?
6 of 6 found this helpful

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For more information, visit the Duke Health General and Consultative Heart Care Center