Skip to content

    Announcements

    Exciting News for WebMD Members!

    We've been busy behind the scenes building new message boards for you. You'll have new and easier ways to find messages, connect with others, and share your stories.

    And, this will all be available on your smartphone or other mobile device!

    What Do You Need to Do?

    The message board you're used to will be closing in the coming weeks. While many of your boards will be making the move to our new home, your posts will not. Want to keep a discussion going? Save posts you want to continue (this includes your member profile story), so that you can re-post them in the new message boards.

    Keep an eye here and on your email inbox, we'll be back in touch soon to give you all the information you need!


    Yours in health,
    WebMD Message Boards Management

    Doctor's responses 3-19-2010
    avatar
    DUKE MEDICINE
    Susannah D Copland, MD, MS posted:
    Hello,

    Several lines of discussions are interested in clomiphene. Here are some thoughts and responses to questions:

    Clomiphene is structurally similar to estrogen. When taken early in a menstrual cycle, it tricks the the hypothalamus (a part of the brain that controls the menstrual cycle) into behaving as if estrogen were low. The hypothalamus pushes the pituitary gland to put out more follicle stimulating hormone, and the ovary gets a bigger push toward ovulation.

    80% of women who do not ovulate will respond to clomiphene and ovulate.

    If the ovary is responding, most will see a LH surge on ovulation predictor kit between 5 and 12 days after the last clomiphene pill.

    Because the ovary can respond with more than one follicle/egg, clomiphene has an 8% risk of twins.

    Because 3/4 of women who do not ovulate will be pregnant by 6-9 cycles of clomiphene, most doctors will start looking into different treatment options if a patient has completed 6 cycles without getting pregnant.

    In women who do ovulate, clomiphene can be used to increase the number of eggs released. Many times intrauterine insemination is used to maximize pregnancy rates. Clomiphene has a lower success rate per cycle in women who are already ovulating. In women who do not ovulate, clomiphene has a 15-20% chance of pregnancy per cycle. In women who do ovulate, clomid with insemination has a 8-10% chance of pregnancy per cycle (2-3 x the pregnancy rate of women with infertility who do not use clomiphene with insemination).

    Now to the specific posts:

    Ovulating


    ladyjane1025 Because clomiphene can cause your ovary to release more than one egg, you may perceive ovulation more. Pelvic discomfort is perceived is reported by some women using clomiphene. The smiley on your kit is a positive LH surge. The egg is released 24-48 hours later, so intercourse on the day of the surge and the day after will get sperm there before the egg is released.

    Follicle growth

    Anon_6592
    If a woman is using hCG shots to trigger ovulation, we will usually give the shot when the follicle is 18-22 mm in diameter, however we see pregnancies with smaller and larger follicles too.

    Have a great week!
    Reply


    Helpful Tips

    New Committee Opinion on Female Fertility TestingExpert
    New Guidelines on Fertility Testing! American Society for Reproductive Medicine (ASRM) released a Committee Opinion on evaluation of the ... More
    Was this Helpful?
    9 of 9 found this helpful

    Related Drug Reviews

    • Drug Name User Reviews

    Report Problems With Your Medications to the FDA

    FDAYou are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

    For more information, visit the Duke Fertility Center