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Male Infertility due to Medications?
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An_191501 posted:
So after a pretty low day yesterday (AF reared her ugly head), my husband and I sat down and talked about our next steps. We've been TTC for 15 months and already have a 4 y.o. girl. When I went in to meet with my dr a few months ago, he asked if anything had changed (medically) for us and I told him that my husband was now taking allopurinol and colchicine daily. He said it wouldn't affect things. Out of desperation yesterday, I looked them up and guess what severly decreases sperm motility? Allopurinol and colchicine! Ugh! I'm hoping this is our answer to why things haven't gone as hoped/planned. Does anyone have any insight on these meds? How long do they stay in his system? Fingers crossed that we found the problem!
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fiannakyn responded:
I dont know what those two do, but I do know it takes about 3 months for new sperm to be made and matured to usefulness. You might ask for a semen analys now, and see if there is any problems before having him go off the meds. IF there is a problem, then he can go off the meds, and take vits (zink and vit C mainly) to help boost, and in 3 months retest.

good luck!!
 
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DUKE MEDICINE
Susannah D Copland, MD, MS responded:
While most medications do not affect sperm production, both allopurinol and colchicine have been been reported to influence semen parameters. Unlike women, who have all their eggs at birth, men are continuously making sperm. The sperm ejaculated today, started their journey in the testicle approximately 70 days prior to ejaculation. Therefore your husband may wish to have a semen analysis and meet with his prescribing doctor to see if any medication alternatives are available. Once a man makes a change in medications that is expected to affect sperm production (stopping medications thought to be harmful, starting medications like clomid to boost production, etc), the next semen analysis should be scheduled in 2-3 months to see if the change was beneficial. Good Luck!
 
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An_191502 replied to Susannah D Copland, MD, MS's response:
My husband is currently not on medications however when he was 3 (in 1978) he had brain cancer and had radiation on his head and back of his neck. He has never been tested and doesn't want to due to the fear of the outcome. I am just wondering what are the chances that he is sterile? I know the only way to find out for sure is a test, but I was just curious if his chances are good that he still can conceive.
 
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tzortzoc replied to Susannah D Copland, MD, MS's response:
I am on avonex(interferon b-1a)treatment, because of multiple sclerosis.
In my latest semen analysis, i had 35m spermatozoa(a year ago 72m)and 35% forward movement(80% a year ago).
What is going on?
Do you think it is related to avonex treatment?
Thank you very much.


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