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clomid vs femera?
blueeyebaby posted:
I am wondering what the difference were between clomid and femera? Do they work the same way? Do you know the success rates for either?
Joel Bernstien, MD responded:
The two medications are very similar in their mechanism of action. I feel that more and more people are moving towards Femara. One difference that I can think of is that, while both have increased risk of multiples (twins, etc), this rate is slightly lower with Femara than Clomid. Others have told me that Clomid side effects are a bit more common. And lastly, Femara is probably slightly more expensive, but both are affordable.

As far as success rates are concerned, this really depends on the underlying cause of the infertility. I do not believe there is a marked difference in the success rates between the two.
blueeyebaby replied to Joel Bernstien, MD's response:
Thank you for the info. I was also wondering if they both work the same, is it comparable to say that if a low dose of clomid didn't work, a low dose of femera wouldn't either?

I used 100mg of clomid to conceive our son back in 2008. I am currently on 150mg clomid to conceive again and one cycle at 150mg had a possible chance of ovulation (progesterone level of 8.5 6dpo) and then the next cycle at 150mg, I had no ovulation. Dr is talking about either 200mg clomid or 2.5 femera.
Joel Bernstien, MD replied to blueeyebaby's response:
My opinion would be that if you fail to ovulated with clomid at 150mg, then it may be time for a referral to an infertility specialist. Obviously your doctor knows you better so I defer to them. I would think going back and starting femara would not be the best use of cycle times

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For more information, visit the Duke Fertility Center