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Kidney transplant and stomach weight gain
An_246749 posted:
Right after my surgery 13 years ago I began having stomach weight gain. Today I exercise minimum of 3 days per week and I am still gaining weight. It seem the only way for me to lose weight is to eat salads only. I hate the stomach weight gain. Any suggestion except stop eating because I am not an over eater.
john-skpt responded:
I suspect that 13 years ago you probably were given prednisone as a part of the immunosuppresant plan. Prednisone definitely changes how, how much, and where the body stores fat.

I don't have any hard evidence for this, but it seems to affect women to a greater degree than men.

Personally it has not bothered me too much, but the weight that I have added DOES seem to build up in the lower abdomen, mostly at or below the level of the navel.

Diet and exercise are the only things I know of that could help. Portion control is vital (remember: prednisone not only changes how the body stores far, it can "turn on" the appetite in a way that is very hard to "turn off".)

Obviously I'm predicating things on the fact that you are taking prednisone; some centers never started folks on that drug, but until lately most of them did. It could be due to anther drug or some shift in metabolism, but we don't have enough info here to guess about that.
Aunt2 replied to john-skpt's response:
I was one of the lucky ones and did not have to take prendisone for more than the first six months. To maintain my weight I have to work ou t3- 5 times per week and that is high intentisity cardio class. Do you know if prograf and cellcept or myfortic causes weight gain or am I justsuffering from middle age, LOL.
john-skpt replied to Aunt2's response:
There really is no action of any of the three drugs that you mention would DIRECTLY lead to weight gain. But I know that a whole lot of transplant patients have a problem with it.

You might ask your nephrologist--if he sees a lot of transplant patients. The transplant surgeons might offer some help but they tend to have such tunnel-vision about graft survival that they rarely think about anything else.

I wonder if something happens to the metabolism when renal patients lose appetite in the later phases of being sick, and the restoration of renal function by transplant enables us to eat again. But maybe the metabolism never quite "re-sets" itself? Just thinking out loud...

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