Skip to content


    Exciting News for WebMD Members!

    We've been busy behind the scenes building new message boards for you. You'll have new and easier ways to find messages, connect with others, and share your stories.

    And, this will all be available on your smartphone or other mobile device!

    What Do You Need to Do?

    The message board you're used to will be closing in the coming weeks. While many of your boards will be making the move to our new home, your posts will not. Want to keep a discussion going? Save posts you want to continue (this includes your member profile story), so that you can re-post them in the new message boards.

    Keep an eye here and on your email inbox, we'll be back in touch soon to give you all the information you need!

    Yours in health,
    WebMD Message Boards Management

    Includes Expert Content
    Knee Implant Rejection?
    Gimpy89139 posted:
    Does anyone know if it is possible for the body to reject a knee replacement implant? I had my knee replaced 19 months ago and have had nothing but pain since. There is no infection and nothing wrong with the prosthesis. I have great bend (130) and extension (0). My OS says it is severe tendonitis and busitis. Doing PT for a 3rd time and there has been little improvement. Just looking for some answers. I am in more pain now than I was before having the replacement. HELP!
    friendlyguy55 replied to debcanada's response:
    Hi Debbie

    I also heard about the cement and I told the allergy doctor about the cement from the studies from the internet and he never heard about it.Well when he did the testing for the metals in my knee he also did the cement test after the metal
    test.I came up negative for the cement thank god.You should call your doctor and tell him about the cement and you want
    that tested as well.I didn't want to have another knee surgery,only to learn that I was postive for cement and needed another surgery no way.Better to be save then sorry,take care and please let me know what happens Lynn
    mikedyott responded:
    I played 200 softball games a year and I was 74. It took me two years to get a needed tkr . I questioned those softball players who had a knee replacement. In all, 30 senior softball players, every operation was successful and of all 30, the longest it took for a guy to feel 100% was 6 months. I had the replacement in December of 2010. PT went fine, I was ahead of all others over 50 according to the therapist. I had 130 degrees of bend and x-rays looked "perfect" but the swelling and pain never went away. It's taken my doctor all these months to determine that my body is rejecting my prosthetic .. or some would say having an "allergic reaction" to the nickel (although the test showed that I was allergic to aluminum and molybdenum as well). My doctor could have made this diagnosis 9 months ago but him "ignoring" me is another story. In the mean time he sent me for blood tests and a neurologist who determined that my femoral nerve had gone dead even though an ultrasound determined that it was still in tact.Then I got a "cold" and after a few days it almost went away but then it came back, and back, and back. It's been 3 months now. My symptoms are drippy nose, full head, crawling feeling in my torso, numb and tingly from the hips down, loss of equilibrium and "flu" feeling in my throat. I'm now thinking that the metal has built in my blood so I'm sensitive to many things, like antibiotics, booze or any pill that's not from a natural food. It's very confusing as my doctor is unresponsive to my calls and has delayed replacing the knee, which actually he is good at doing, since January 2012. And now his office says it'll be 8 more weeks because they have to send to Europe for the "chemically pure titanium" prosthesis. I got on line to find out if anyone has had a similar "allergic" reaction or maybe my 3 months of sickness is due to something else.?
    friendlyguy55 replied to mikedyott's response:
    Hi mikedyott
    If i was you i would get a second opion from another doctor.If you wait to long you could end up very sick or worse.I am allergic to manganise meta,l my hardware in my knee only has 1% but i been having severe reaction to the metal.Today i found out from the second doctor from an referal that he
    agrees with my doctor and the hardware in my knee has to come out.I too have the simpons like you have and also feel
    sick to my stomack even though i am not sick.Some times i have to force myself to eat.They also just did a bone scan in my knee in nucalar med.and foung that i have lots of imformation inside my bone from the matal managise.Your doctor sounds like a quack.Look for another doctor before its
    late.Take care and please let me know what happens Lynn
    debcanada replied to mikedyott's response:
    My replacement was June 2009 and like you I have such a "sick" feeling all the time. Allergy testing starts tomorrow and I really hope it will give me some answers. I have had a drippy nose since the surgery and recently found out I have a low white blood cell count. Like many others on this site, I feel the decision to have this tkr may have been the worst decision I have ever made. My right knee needs to be replaced but that is not going to happen.
    Please let me know what your doctors find out and please find a doctor that is willing to listen and may actually care what kind of pain you are in. I think my current doctor is, perhaps, just waiting for me to die from this. Some days I feel it may be my last.
    Hope you are feeling better. I do care what happens to you and I definitely empathize.
    debcanada replied to friendlyguy55's response:
    Lynn, Just wondering if you have new information on your knee? I have been so sick for two weeks and wonder if it related to this knee. Although I can't imagine a revision, if a doctor would guarantee I would feel like my OLD self, I would have it today! Hope you are feeling better. Please keep in touch.
    friendlyguy55 replied to debcanada's response:
    Hi I hope you are feeling better
    i have no choice,my knee has to be replace with another.
    I am breaking out all over my body and i take meds. for it.I
    will be going in for surgery right after 4th of july.I too feel sick all over but yet i'am not sick,thats because i'm allgertic too that
    magansise in my hardware and it is only 1 % lol.
    It sounds like you are allgertic to your hardware too,i think you will test postive too.Take care and let me know anything new
    GOD BLESS Lynn
    mermaidincolorado replied to debcanada's response:
    I have had TWO knee replacements since Jan 2009. Long story short, I finally found out (from my own research) that I'm allergic to Nickel. I told the first doctor that i had a problem with hardware ad that I had to have it removed from my body 4 times before he did a partial knee replacement on m. He should have done a metal allergy test on me but blew it off. Google MELISA TEST it is done in Calif but has Drs. in most of the US States that can do it. I'm in Colo. I've been sick for over 2 years, nauseous, shakey, fever, headace, HORRIFIC PAIN, can't bear weight on my left leg and it's getting worse. I'm finally seeing an allergy Specialist this Wed. I had a complete revision surgery on my left knee for nothing. I am so angry. These doctors should be liable and should always test you BEFORE putting a foreign object in your body.
    mjob1953 responded:
    Oh Yes that is what is happening to me. I had a knee replacement may of 2010 and to this day it is a nightmare. The doctor went back in july 2010 to try to see why it would not straighten out, well it was scare tissue. Went through 3 hours of surgery to try to fix, guess what it is still swollen and cannot bend back very far. He put me thru all kids of test for infection and there is none. After all that he is convinced I trying to reject my knee because I am allergic to nickel. I am going to have to replace I guess when I can afford. I just hope I can walk a little better than this before I die. Anaother prob my pain meds make my blood sugar soar, so I cant take very often.
    AliFant responded:
    Do the metal-Ltt test for allergy, and research in internet. good look...
    AliFant replied to friendlyguy55's response:
    do not trust the patches test, I first have the metal-LTT test for metal allergy that included the cement and came positive then the surgeon sent me to the allergy Dr. and he did the patch test and came negative, the best test is the test that take blood sample the one I mention. Good Luck!
    friendlyguy55 replied to AliFant's response:
    I had the allergy patch test done by the allergy doctor and i also had the blood test.My surgery was 2 yrs. and 8 months
    ago.My surgery will be this July 31 2012.I hope it will take care of my problems which began about one week after my surgery.
    I asked my doctor if i could be allergic to my hardware back
    then,and he said no,because it is very rare.I feel like i lost almost 3 yrs.of my time.Please let me know how you are doing
    now. Lynn
    gloriasburgess responded:
    omg YES, I am so sorry you are going throught this, i just had my 3rd knee put in ,3rd in just 2 and a half years, i had a infection with the first right in the hospital,that doctor refused to believe there was anything wrong, after 7 months it hit my bloodstream, 2nd surgern did emergencey surgery after 3 months and almost dying,it was not right he said there was nothing wrong i was in so much pain,swelling my knee cap stuck out of my calf,i fired him and went to lancaster to a wonderful surgern who would not touch my knee untill i went through a hundred tray allergy test at hershey, turns out i was allergic to the colbolt that is used in most knees,also the cement and glue, thank god i found him,i am 5 weeks post opp and can not believe how fast i am healing, my kneecap in the area it should be in not perfect because of all the damage caused from doctors who just don,t have a clue, please insist on a allergy test,do not listen to them if they tell you that it is to rare,it is more common then most of these surgerns know.i really hope that you get this fixed asap.good luck.always remember you know your own body, you know when something is wrong,if you doc will not do anything,fire him and find another,
    gloriasburgess replied to mpapkov12's response:
    hershey medical is the only place that does the 100 tray test,i found out that i was allergic to colbolt, and something in the bone cement and glue,i'm sure you can find a allergey doc to test for those things found in knee replacements,good luck,after 2 and a half years,almost dying, almost loseing my leg,i am 5 weeks post opp with my 3rd knee and healing so fast now that my body is not trying to fight my knee.
    notworkingtwonewknees replied to mpapkov12's response:
    I am 10 months into bilateral knee replacements. I was fine until 4 months when everything started to go wrong. I had pain constantly. I continued to do therapy and have not stopped. I m not overweight or a complaining person but I want my life back. I just went back to see my orthopaedic surgeon who sent me to a physiatrist who did nerve studies; also did lumbar MRI and brain MRI. All negative. I have good knee movements when moved by doctor and xrays of knees look really good but I cannot walk properly, my knees are stiff and unstable. One knee gives off a popping sound when I get up. Dr. gave me shots for tedonitis and this has helped pain but no resolution as to why I cannot walk properly. Also prednisone. I have in fact fallen. As I am allergic to lots of medications, ears being pierced and cant wear contact lens how do I find out if I could be allergic to some material in the knees. Or what do I do next. HELP.
    KevinHilton replied to ethert's response:
    Although I have never heard of a phenylenediamine allergy, becareful about over-reading the results of Allergen Patch Testing. Cutaneous sensitivity in most cases is not predictive of sensitivity internally. Cutaneous sensitivity usually requires dendritic cells to be present as the allergen presenting cells, and to my knowledge these cells are not present internally. I don't have any hard statistics to back up my statement, but in about 99 cases out of 100, the cause for constant pain after joint replacement is likely to be due to some other cause other than implant hypersensitivity. Metal on metal hips are one thing, however allergy to total knee replacement parts are another. There has been no documented or published consensus of what a normal Cobalt or Chromium blood level should be in well functioning total knees. Even less is known about more rarer serum levels.

    Helpful Tips

    Pain after Knee ReplacmentExpert
    For most people a knee replacement can predictably eliminate pain and restore function. This is not to say that the operation is not ... More
    Was this Helpful?
    59 of 76 found this helpful

    Related Drug Reviews

    • Drug Name User Reviews

    Report Problems With Your Medications to the FDA

    FDAYou are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

    For more information, visit the Duke Health Joint Replacement Center