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PERSONALIZED MEDICINE IN LUNG CANCER
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An_206445 posted:
The results summarized by Oxnard and Miller show that genetic testing is critical for clinical decision-making in this cancer. Depending on the population, the proportion of NSCLC patients who have EGFR-activating mutations may be in the range of 15% to 40%. Is it possible that the remaining set of patients have other genetic changes that might help us find a suitable treatment? It has been discovered that subsets of NSCLC patients have mutations in BRAF, mutations resulting in activation of the AKT pathway, amplification of ErbB2, amplification of MET, or translocation of EML and ALK4. Drugs that specifically target these changes are either available or in clinical trials for this or other tumor types.
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0 Replies |Report This| Share this:PERSONALIZED MEDICINE IN LUNG CANCERThe results summarized by Oxnard and Miller show that genetic testing is critical for clinical decision-making in this cancer. Depending on the population, the proportion of NSCLC patients who have EGFR-activating mutations may be in the range of 15% to 40%. Is it possible that the remaining set of patients have other genetic changes that might help us find a suitable treatment? It has been discovered that subsets of NSCLC patients have mutations in BRAF, mutations resulting in activation of the AKT pathway, amplification of ErbB2, amplification of MET, or translocation of EML and ALK4. Drugs that specifically target these changes are either available or in clinical trials for this or other tumor types.
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