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DR V: Question Re: Prescribing antibiotics while on Cellcept:
lupylisa44 posted:
Recently someone on another lupus site that I am on said that their doctor prescribed cellcept but insisted that she also take an antibiotic while on it. She was told that this is common practice. I have never heard this before and was wondering if, in fact, it is common and, if so, Why?

From what I have read, it says many antibiotics can actually interfere with the absorbtion/bioavailability of Cellcept.

I have always been told to take antibiotics only when absolutely necessary.

With love, with patience and with faith, we'll make our way.
nancyj95 responded:
I have been on Cell Cept for about 3 years (daily) and although I'm only on 500 mg 2x a day now, I have never heard about this. My doc says I will never be able to go off it. Was on triple this dose for almost a year when I was in a constant flare. I'm one of those who'll probably never be able to take advantage of meds which might get me off steroids. I have latent TB and chronic hepatitis-two conditions which although under control have a big influence on what I can do.
Like you, I only take antibiotics when really needed.
lupylisa44 replied to nancyj95's response:
With love, with patience and with faith, we'll make our way.
R Swamy Venuturupalli, MD, FACR replied to lupylisa44's response:
A prior study showed that hospitalized lupus patients were at much higher risk for PCP (pneumocystic carinii) than hospitalized RA patients. Hence, it might be prudent to consider antibiotic prophylaxis in situations where lupus patients are being immunosuppressed to a significant degree. One example of such a situation would be some is being prescribed high doses of cellcept along with moderate to high doses of steroids. Usually, prophylaxis is in the form of an antibiotic like bactrim, pentamidine or atovoquone. The use of bactrim for prophylaxis should be weighed against a potential risk for causing lupus flares (especially skin flares) since it is a sulfa antibiotic, and sulfa drugs may cause lupus flares.

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