Skip to content


    Exciting News for WebMD Members!

    We've been busy behind the scenes building new message boards for you. You'll have new and easier ways to find messages, connect with others, and share your stories.

    And, this will all be available on your smartphone or other mobile device!

    What Do You Need to Do?

    The message board you're used to will be closing in the coming weeks. While many of your boards will be making the move to our new home, your posts will not. Want to keep a discussion going? Save posts you want to continue (this includes your member profile story), so that you can re-post them in the new message boards.

    Keep an eye here and on your email inbox, we'll be back in touch soon to give you all the information you need!

    Yours in health,
    WebMD Message Boards Management

    Includes Expert Content
    Question for Dr. V
    lupylisa44 posted:
    I am curious to know your opinion about low dose naltrexone for lupus. My Primary care doctor is a Harvard M.D. who practices integrative medicine. She suggested that I try low dose naltrexone to help relieve many painful symptoms of lupus. Do you know anything about this treatment? If so, what is your opinion of it?

    With love, with patience and with faith, we'll make our way.
    lupylisa44 responded:
    With love, with patience and with faith, we'll make our way.
    R Swamy Venuturupalli, MD, FACR responded:
    Naltrexone is an inexpensive generic pharmaceutical approved by the United States Food and Drug Administration since 1984 for treating opiate and alcohol addiction. Usually doses of about 0.5 mg/kg of body weight are used to treat chronic opioid or alcohol addiction. However, recent observations indicate that low doses of naltrexone (0.08 mg/kg) may have beneficial effects on the immune system. There have been some preliminary studies suggesting benefit of LDN in Crohn's disease and MS as well as HIV/AIDS, certain types of cancer. Side effects seem to be usually both mild and transitory.

    One small nightly dose of Naltrexone has the effect of temporarily blocking certain opioid receptors. This causes a several-fold increase in endogenous endorphins (opiate-like chemicals produced naturally in the body) in the morning when a patient awakens. This leads to a positive effect on the mood and if we were to extrapolate from animal studies, seems to help with immune function regulation.

    According to some patient reports, the endorphin increase at night can also make dreams more vivid and create disturbances in sleep. I have no experience prescribing this medication, and at this time it remains experimental for the treatment of autoimmune disease.

    With Lupus

    WebMD's Day2Night will help you develop personal coping strategies for living with lupus – at home,
    at work, or with family
    and friends.
    Visit Lupus Day2Night

    Helpful Tips

    Vitamin DExpert
    Lupus patients are rightfully told to avoid the sun since it can flare the disease. But guess what... by doing so you are setting yourself ... More
    Was this Helpful?
    94 of 124 found this helpful

    Related Drug Reviews

    • Drug Name User Reviews

    Report Problems With Your Medications to the FDA

    FDAYou are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.